Primary central nervous system lymphoma pathophysiology: Difference between revisions
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Image:Microscopic pathological image of primary central nervous system lymphoma image 1.jpg|Micrograph from a brain biopsy demonstrating a primary CNS lymphoma with the characteristic perivascular distribution composed of large cells with prominent nucleoli, on HPS stain.<ref name=pcnslwikipediA1>Primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016</ref></sub></gallery> | Image:Microscopic pathological image of primary central nervous system lymphoma image 1.jpg|<sub>Micrograph from a brain biopsy demonstrating a primary CNS lymphoma with the characteristic perivascular distribution composed of large cells with prominent nucleoli, on HPS stain.<ref name=pcnslwikipediA1>Primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016</ref></sub></gallery> | ||
==References== | ==References== |
Revision as of 19:04, 18 February 2016
Primary central nervous system lymphoma Microchapters |
Differentiating Primary Central Nervous System Lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathogenesis
Associated Conditions
Gross Pathology
- Primary central nervous system lymphoma presents as a solitary or multiple, well-defined or infiltrating mass lesion/s that can arise in the cortex, white matter, or deep grey matter (more common in low-grade lesions).[1]
- They may demonstrate areas of necrosis, especially in immunodeficient patients.
- Origin of malignant cells is not well understood as intra-axial CNS does not have lymphatic system.[1]
Microscopic Pathology
- The vast majority (>90%) of primary central nervous system lymphoma are B-cell in origin: diffuse large B-cell lymphoma and high-grade Burkitt-like B-cell lymphoma.[1]
- Malignant cells tend to accumulate around blood vessels.
- Low-grade tumors are more frequently T-cell in origin.[1]
- On microscopic histopathological analysis, primary central nervous system lymphoma is characterized by a perivascular distribution composed of large cells with prominent nucleoli.[2]
Gallery
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Micrograph from a brain biopsy demonstrating a primary CNS lymphoma with the characteristic perivascular distribution composed of large cells with prominent nucleoli, on HPS stain.[2]
References
- ↑ 1.0 1.1 1.2 1.3 Pathology of primary central system lymphoma. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/primary-cns-lymphoma. Accessed on February 18, 2016
- ↑ 2.0 2.1 Primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016