Mucoepidermoid carcinoma pathophysiology: Difference between revisions
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*Mucoepidermoid carcinomas arise from mucous cells, which are normally involved in the secretion of mucous and the protection of surrounding [[tissue]]. | *Mucoepidermoid carcinomas arise from mucous cells, which are normally involved in the secretion of mucous and the protection of surrounding [[tissue]]. | ||
*The pathogenesis of mucoepidermoid carcinoma consists of abnormal production of mucin from [[Mucous lining|mucous cells]], associated with the aberrant overgrowth of squamous and [[epidermoid cells]]. | *The pathogenesis of mucoepidermoid carcinoma consists of abnormal production of mucin from [[Mucous lining|mucous cells]], associated with the aberrant overgrowth of squamous and [[epidermoid cells]]. | ||
==Genetics== | ==Genetics== | ||
*Development of mucoepidermoid carcinomas may be the result of multiple genetic [[mutatio]]ns. | *Development of mucoepidermoid carcinomas may be the result of multiple genetic [[mutatio]]ns. | ||
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:*[[Fusion gene|MECT1]] fusion gene | :*[[Fusion gene|MECT1]] fusion gene | ||
:*[[Fusion gene|MAML2]] fusion gene | :*[[Fusion gene|MAML2]] fusion gene | ||
==Associated Conditions== | ==Associated Conditions== | ||
*Mucoepidermoid carcinomas have no associated conditions. | *Mucoepidermoid carcinomas have no associated conditions. | ||
==Gross Pathology== | ==Gross Pathology== | ||
*On gross pathology, mucoepidermoid carcinoma has a cystic, solid or mixed appearance. | *On gross pathology, mucoepidermoid carcinoma has a cystic, solid or mixed appearance. | ||
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:*Normally located on the parotid or [[submandibular gland]] | :*Normally located on the parotid or [[submandibular gland]] | ||
:*Gray or white color, with mucin filled [[cysts]] | :*Gray or white color, with mucin filled [[cysts]] | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
*On microscopic histopathological analysis, the characteristic feature of mucoepidermoid carcinomas, include: | *On microscopic histopathological analysis, the characteristic feature of mucoepidermoid carcinomas, include: | ||
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:*Intermediate grade is characterized by intermediate features | :*Intermediate grade is characterized by intermediate features | ||
:*High grade is characterized by poorly differentiated with cellular [[Pleomorphism|pleomorphism,]] high proportion of squamous cells, and solid with few if any cysts | :*High grade is characterized by poorly differentiated with cellular [[Pleomorphism|pleomorphism,]] high proportion of squamous cells, and solid with few if any cysts | ||
==Gallery== | ==Gallery== | ||
<gallery> | <gallery> | ||
Revision as of 16:36, 19 February 2016
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Mucoepidermoid carcinoma Microchapters |
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Differentiating Mucoepidermoid Carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Mucoepidermoid carcinoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Mucoepidermoid carcinoma pathophysiology |
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Risk calculators and risk factors for Mucoepidermoid carcinoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Mucoepidermoid carcinomas arise from mucous cells, which is normally involved in the secretion of mucous and the protection of surrounding tissue. The pathogenesis of mucoepidermoid carcinoma consists of abnormal production of mucin from mucous cells, associated with the aberrant overgrowth of squamous and epidermoid cells. Genes involved in the pathogenesis of mucoepidermoid carcinoma include MECT1 and MAML2 fusion genes. On gross pathology, mucoepidermoid carcinomas have a cystic, solid or mixed appearance, the tumor size ranges from 1 to 8 cm, and they are normally located on the parotid or submandibular gland.[1] On microscopic histopathological analysis, mucoepidermoid carcinomas are characterized by mucous cells with abundant fluffy cytoplasm and large mucin vacuoles.[1]
Pathogenesis
- Mucoepidermoid carcinomas arise from mucous cells, which are normally involved in the secretion of mucous and the protection of surrounding tissue.
- The pathogenesis of mucoepidermoid carcinoma consists of abnormal production of mucin from mucous cells, associated with the aberrant overgrowth of squamous and epidermoid cells.
Genetics
- Development of mucoepidermoid carcinomas may be the result of multiple genetic mutations.
- Genes involved in the pathogenesis of include:
Associated Conditions
- Mucoepidermoid carcinomas have no associated conditions.
Gross Pathology
- On gross pathology, mucoepidermoid carcinoma has a cystic, solid or mixed appearance.
- Other gross pathology findings, include:
- The tumor size ranges from 1 to 8 cm
- Normally located on the parotid or submandibular gland
- Gray or white color, with mucin filled cysts
Microscopic Pathology
- On microscopic histopathological analysis, the characteristic feature of mucoepidermoid carcinomas, include:
- Mucus secreting cells (visible with musicarmine staining)
- Composed of three cell types: epidermoid, intermediate, and mucin producing
- Mucin vacuoles may be rare; in a superficial glance (mimics squamous cell carcinoma)
- Mucoepidermoid tumors are graded histologically into: low grade, intermediate grade, and high grade.
- Low grade is characterized by well-differentiated cells with little cellular atypia, high proportion of mucous cells, and prominent cyst formation
- Intermediate grade is characterized by intermediate features
- High grade is characterized by poorly differentiated with cellular pleomorphism, high proportion of squamous cells, and solid with few if any cysts
Gallery
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![Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. H & E stain.[1]](/images/7/73/Mucoepidermoid_carcinoma_%282%29_HE_stain.jpg)
Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. H & E stain.[1] -
![Histopathologic image of mucoepidermoid carcinoma of the major salivary gland.[1]](/images/1/17/Mucoepidermoid_carcinoma_%283%29_HE_stain.jpg)
Histopathologic image of mucoepidermoid carcinoma of the major salivary gland.[1] -
![Histopathologic image of mucoepidermoid carcinoma. Postoperative recurrence of the submandibular tumor. Alcian blue-PAS stain.[1]](/images/8/86/Mucoepidermoid_carcinoma_%281%29_AB-PAS_stain.jpg)
Histopathologic image of mucoepidermoid carcinoma. Postoperative recurrence of the submandibular tumor. Alcian blue-PAS stain.[1] -
![Gross pathology mucoepidermoid carcinoma.[1]](/images/1/1e/Gross_MEC.jpg)
Gross pathology mucoepidermoid carcinoma.[1]
![Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. H & E stain.[1]](/index.php/File:Mucoepidermoid_carcinoma_(2)_HE_stain.jpg)
![Histopathologic image of mucoepidermoid carcinoma of the major salivary gland.[1]](/index.php/File:Mucoepidermoid_carcinoma_(3)_HE_stain.jpg)
![Histopathologic image of mucoepidermoid carcinoma. Postoperative recurrence of the submandibular tumor. Alcian blue-PAS stain.[1]](/index.php/File:Mucoepidermoid_carcinoma_(1)_AB-PAS_stain.jpg)
![Gross pathology mucoepidermoid carcinoma.[1]](/index.php/File:Gross_MEC.jpg)