Epithelioid sarcoma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Other diagnostic studies for epithelioid sarcoma include genetic testing and immunohistochemistry.

Genetic Testing

• Loss of INI1 (also known as hSNF5 and SMARCB1) which is a member of SWI/SNF multi-subunit chromatin remodeling complex located on the long arm of chromosome 22 (22q11.2) has been a diagnostic modality of epithelioid sarcoma.
• Immunohistochemical staining of INI1 is available and can be used for the diagnosis of epithelioid sarcoma. MRI is the diagnostic modality of choice for imaging prior to biopsy and pathologic diagnosis, with the primary role being the determination of anatomic boundaries.

Immunohistochemistry

• Immunohistochemical staining of INI1 is available and can be used for the diagnosis of epithelioid sarcoma.
• Vimentin reactivity
• Pankeratin AE1/AE3 and epithelial membrane antigen
• Negative S100