Seminoma differential diagnosis: Difference between revisions

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Revision as of 16:23, 25 February 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Differentiating Seminoma from other Diseases

The most common presentation of testicular seminoma is a painless testicular mass.^[1] The main differential for testicular mass in young adults is non-seminomatous germ cell tumor (NGCT) which usually appear more heterogenous, often with cysts and calcification.^[2] Lymphadenopathy of non-seminomatous germ cell tumor may enhance more heterogenously. Testicular lymphoma is the main differential diagnosis to consider when para-aortic lymphadenopathy is the presenting finding or in the setting of bilateral testicular lesions.^[2]

Testicular seminoma must be differentiated from:^[3]^[4]

Differential diagnosis of testicular seminoma

Unilateral testicular mass

Bilateral testicular mass

❑ Neoplastic

Non seminomatous germ cell tumours:

Testicular teratoma
Testicular epidermoid (teratoma with ectodermal elements only)
Choriocarcinoma
Embryonal cell carcinoma
Yolk sac tumor (endodermal sinus tumor)
Mixed germ cell tumour

Sex cord/stromal tumours (~2% of testicular malignancies):

Metastasis to testis

❑ Non-neoplastic

Testicular cyst
Tubular ectasia of rete testes (can be bilateral)
Focal orchitis
Focal intratesticular haemorrhage
Ischaemia/infarction (e.g. testicular torsion)
Segmental testicular infarction
Intra testicular adrenal rest
Focal granulomatous disease:
Caseating/infective (e.g. tuberculosis)
Non caseating (e.g. sarcoidosis)
Supranumerary testes (polyorchidism)
Intratesticular varicocele
Intratesticular arteriovenous malformation

WHO grade II

References

↑ Clinical presentation of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiopaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 25, 2016
↑ ^2.0 ^2.1 Differential diagnosis of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiopaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 25, 2016
↑ Unilateral testicular lesions. Dr Yuranga Weerakkody and Dr Vinod G Maller et al. Radiopaedia 2016. http://radiopaedia.org/articles/unilateral-testicular-lesions. Accessed on February 25, 2016
↑ Bilateral testicular lesions. Dr Matt A. Morgan and Dr Vinod G Maller et al. Radiopaedia 2016. http://radiopaedia.org/articles/bilateral-testicular-lesions. Accessed on February 25, 2016

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[clinicslpresntatioontesticularseminoma1-1] Clinical presentation of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiopaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 25, 2016

[differentialdiagnopsisoftesticulartyeratoma1-2] 2.0 ^2.1 Differential diagnosis of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiopaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 25, 2016

[Unilateraltesticularlesions1-3] Unilateral testicular lesions. Dr Yuranga Weerakkody and Dr Vinod G Maller et al. Radiopaedia 2016. http://radiopaedia.org/articles/unilateral-testicular-lesions. Accessed on February 25, 2016

[Bilateraltesticularlesions1-4] Bilateral testicular lesions. Dr Matt A. Morgan and Dr Vinod G Maller et al. Radiopaedia 2016. http://radiopaedia.org/articles/bilateral-testicular-lesions. Accessed on February 25, 2016

[1]

[2]

[3]

[4]

@@ Line 12: / Line 12: @@
 {{familytree/start |summary=Testicular mass}}
-{{familytree |boxstyle=background: #DCDCDC;| | | | | | | | | | | | | A01| | | | | | | | | | | | | |A01=<div style="width: 12em; padding:0.2em;">'''Differential diagnosis of testicular seminoma'''</div>}}
+{{familytree |boxstyle=background: #DCDCDC;| | | | | | | | | | | | | A01| ||A01=<div style="width: 12em; padding:0.2em;">'''Differential diagnosis of testicular seminoma'''</div>}}
-{{familytree |boxstyle=background: #DCDCDC;| | | | | | | |,|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | | | | | | | | | |}}
+{{familytree |boxstyle=background: #DCDCDC;| | | | | | | |,|-|-|-|-|-|^|-|-|-|-|-|.| | | ||}}
-{{familytree |boxstyle=background: #DCDCDC;| | | | | | | B01 | | | | | | | | | | B02 | | | | | | | | | | | | | | | |B01=<div style="width: 12em; padding:0em;">'''Unilateral testicular mass''' </div>|B02=<div style="width: 12em; padding:0em;">'''Bilateral testicular mass'''</div>}}
+{{familytree |boxstyle=background: #DCDCDC;| | | | | | | B01 | | | | | | | | | | B02 | | | | | | |B01=<div style="width: 12em; padding:0em;">'''Unilateral testicular mass''' </div>|B02=<div style="width: 12em; padding:0em;">'''Bilateral testicular mass'''</div>}}
-{{familytree |boxstyle=background: #DCDCDC;| | | | | | | F01 | | | | | | | | | | F02 | | | | | | | | | | | | | | | |F01=<div style="width: 12em; padding:0em;">'''WHO grade I / II''' </div>|F02=<div style="width: 12em; padding:0em;">'''WHO grade II'''</div>}}
+{{familytree |boxstyle=background: #DCDCDC;| | | | | | | F01 | | | | | | | | | | F02 | | | | | | | | | | | | | | | |F01=<div style="width: 12em; padding:0em;">❑ Neoplastic<br>
-{{familytree |boxstyle=background: #DCDCDC;| | | | | | | |!| | | | | |,|-|-|-|v|-|^|-|v|-|-|-|.| | | | | | | | | | | | | | |}}
+*Non seminomatous germ cell tumours:
-{{familytree |boxstyle=background: #DCDCDC;| | | | | | | |!| | | | | C01 | | C02 | | C03 | | C04 | | | | | | | | | | | | | |C01=<div style="width: 9em; padding:0.2em;">'''[[Fibrillary astrocytoma]]''' </div>|C02=<div style="width: 9em; padding:0.2em;">'''[[Gemistocytic astrocytoma]]'''</div>|C03=<div style="width: 9em; padding:0.2em;">'''[[Protoplasmic astrocytoma]]'''</div>|C04=<div style="width: 9em; padding:0.2em;">'''[[Oligoastrocytoma]]'''</div>}}
+:*Testicular teratoma
-{{familytree |boxstyle=background: #DCDCDC;| |,|-|-|-|v|-|^|-|v|-|-|-|.| | | | | | | | | | | | | | | | | |}}
+:*Testicular epidermoid (teratoma with ectodermal elements only)
-{{familytree |boxstyle=background: #DCDCDC;| D01 | | D02 | | D03 | | D04 | | | | | | | | | | | | | | | | | | | | |D01=<div style="width: 9em; padding:0.2em;">'''[[Pilocytic astrocytoma]]''' </div>|D02=<div style="width: 9em; padding:0.2em;">'''Pilomyxoid astrocytoma'''</div>|D03=<div style="width: 9em; padding:0.2em;">'''[[Subependymal giant cell astrocytoma]]'''</div>|D04=<div style="width: 9em; padding:0.2em;">'''[[Pleomorphic xanthoastrocytoma]]'''</div>}}
+:*Choriocarcinoma
-{{familytree |boxstyle=background: #DCDCDC;| E01 | | E02 | | E03 | | E04 | | | | | | | | | | | | | | | | | | | | |E01=<div style="width: 9em; padding:0.2em;">'''WHO grade I''' </div>|E02=<div style="width: 9em; padding:0.2em;">'''WHO grade II'''</div>|E03=<div style="width: 9em; padding:0.2em;">'''WHO grade I'''</div>|E04=<div style="width: 9em; padding:0.2em;">'''WHO grade II'''</div>}}
+:*Embryonal cell carcinoma
+:*Yolk sac tumor (endodermal sinus tumor)
+:*Mixed germ cell tumour
+*Sex cord/stromal tumours (~2% of testicular malignancies):
+:*[[Leydig cell tumor]]
+:*[[Sertoli cell tumor]]
+*Metastasis to testis
+❑ Non-neoplastic<br>
+*Testicular cyst
+*Tubular ectasia of rete testes (can be bilateral)
+*Focal orchitis
+*Focal intratesticular haemorrhage
+*Ischaemia/infarction (e.g. [[testicular torsion]])
+*Segmental testicular infarction
+*Intra testicular adrenal rest
+*Focal granulomatous disease:
+*Caseating/infective (e.g. [[tuberculosis]])
+*Non caseating (e.g. [[sarcoidosis]])
+*Supranumerary testes ([[polyorchidism]])
+*[[varicocele|Intratesticular varicocele]]
+*Intratesticular arteriovenous malformation </div>|F02=<div style="width: 12em; padding:0em;">'''WHO grade II'''</div>}}
 {{familytree/end}}

Seminoma differential diagnosis: Difference between revisions

Revision as of 16:23, 25 February 2016

Overview

Differentiating Seminoma from other Diseases

References

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