Hypergammaglobulinemia pathophysiology: Difference between revisions
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===Type 1 hypergammaglobulinemia=== | ===Type 1 hypergammaglobulinemia=== | ||
*The tumor necrosis factor super family member 5 (''TNFSF5'') gene mutation is involved in the pathogenesis of type 1 hypergammaglobulinemia. | |||
*Type 1 hypergammaglobulinemia is transmitted in x-linked recessive pattern. | |||
mutation in the Tumor Necrosis Factor Super Family member 5 (TNFSF5) gene, which codes for CD40 ligand | |||
==References== | ==References== | ||
Revision as of 20:30, 25 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Hypergammaglobulinemia is an immunoproliferative disorder with elevated levels of gamma globulin (immunoglobulins or antibodies).[1][2]
Pathophysiology
- Hypergammaglobulinemia is an immunoproliferative disorder which arises from B cells, which are a type of white cells that are normally involved in the development of humoral immunity by secreting antibodies.[3]
- The majority of the hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM) because this is the default immunoglobulin type prior to class switching.[1]
- Hypergammaglobulinemias may also be caused by a deficiency in the other major types of immunoglobulins.[1][4]
- The term "hypergammaglobulinemia" refers to the position of the excess of proteins after serum protein electrophoresis (found in the gammaglobulin region).[1]
Type 1 hypergammaglobulinemia
- The tumor necrosis factor super family member 5 (TNFSF5) gene mutation is involved in the pathogenesis of type 1 hypergammaglobulinemia.
- Type 1 hypergammaglobulinemia is transmitted in x-linked recessive pattern.
mutation in the Tumor Necrosis Factor Super Family member 5 (TNFSF5) gene, which codes for CD40 ligand
References
- ↑ 1.0 1.1 1.2 1.3 Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.
- ↑ Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.
- ↑ B cell. Wikipedia. https://en.wikipedia.org/wiki/B_cell Accessed on February 24, 2016.
- ↑ Immunoproliferative disorder. Wikipedia. Accessed on February 24, 2016.