Mast cell tumor pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathophysiology== | ==Pathophysiology== | ||
Mast cells are bone marrow derived cells that are widely distributed in tissues. They store various biologically active mediators, such as heparin and histamine. | Mast cells are bone marrow derived cells that are widely distributed in tissues. They store various biologically active mediators, such as heparin and histamine. 1. | ||
*A mast cell originates from the [[bone marrow]] and is normally found throughout the [[connective tissue]] of the body. | *A mast cell originates from the [[bone marrow]] and is normally found throughout the [[connective tissue]] of the body. | ||
*It is a normal component of the [[immune system]] and as it releases [[histamine]] it is associated with [[allergy|allergic reactions]]. | *It is a normal component of the [[immune system]] and as it releases [[histamine]] it is associated with [[allergy|allergic reactions]]. | ||
*Mast cell [[granule]]s contain [[histamine]], [[heparin]], [[platelet-activating factor]], and other substances.<ref name=saph>{{cite journal |author=Brière C |title=Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog |journal=Can Vet J |volume=43 |issue=8 |pages=620-2 |year=2002 |id=PMID 12170840}}</ref> | *Mast cell [[granule]]s contain [[histamine]], [[heparin]], [[platelet-activating factor]], and other substances.<ref name=saph>{{cite journal |author=Brière C |title=Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog |journal=Can Vet J |volume=43 |issue=8 |pages=620-2 |year=2002 |id=PMID 12170840}}</ref> | ||
*Mediator release from mast cells has a central role in the development of type 1 hypersensitivity. | |||
*In systemic mastocytosis, abnormal proliferation and microscopic infiltration of mast cells involves skin, [[bone marrow]], [[gastrointestinal tract]], [[liver]], and [[spleen]]. | |||
*It is thought that the effects of mastocytosis relate at least in part to mediator release | |||
==References== | ==References== | ||
Revision as of 15:21, 29 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Mast cells are bone marrow derived cells that are widely distributed in tissues. They store various biologically active mediators, such as heparin and histamine. 1.
- A mast cell originates from the bone marrow and is normally found throughout the connective tissue of the body.
- It is a normal component of the immune system and as it releases histamine it is associated with allergic reactions.
- Mast cell granules contain histamine, heparin, platelet-activating factor, and other substances.[1]
- Mediator release from mast cells has a central role in the development of type 1 hypersensitivity.
- In systemic mastocytosis, abnormal proliferation and microscopic infiltration of mast cells involves skin, bone marrow, gastrointestinal tract, liver, and spleen.
- It is thought that the effects of mastocytosis relate at least in part to mediator release
References
- ↑ Brière C (2002). "Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog". Can Vet J. 43 (8): 620–2. PMID 12170840.