Mast cell tumor pathophysiology: Difference between revisions
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*Mast cells express a cell surface receptor, c-kit (CD117), which is the receptor for stem cell factor. In laboratory studies, stem cell factor appears to be important for the proliferation of mast cells. | *Mast cells express a cell surface receptor, c-kit (CD117), which is the receptor for stem cell factor. In laboratory studies, stem cell factor appears to be important for the proliferation of mast cells. | ||
*Mutations of the c-kit receptor, leading to uncontrolled stimulation of the receptor, is a cause for the disease. | *Mutations of the c-kit receptor, leading to uncontrolled stimulation of the receptor, is a cause for the disease. | ||
==Genetics== | ==Genetics== | ||
Revision as of 14:08, 1 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
- A mast cell originates from the bone marrow and is normally found throughout the connective tissue of the body.
- It is a normal component of the immune system and as it releases histamine it is associated with allergic reactions.
- Mast cell granules contain histamine, heparin, platelet-activating factor, and other substances.[1]
- Mediator release from mast cells has a central role in the development of type 1 hypersensitivity.
- In systemic mastocytosis, abnormal proliferation and microscopic infiltration of mast cells involves skin, bone marrow, gastrointestinal tract, liver, and spleen.[2]
- It is thought that the effects of mastocytosis relate at least in part to mediator release.
- Mast cells express a cell surface receptor, c-kit (CD117), which is the receptor for stem cell factor. In laboratory studies, stem cell factor appears to be important for the proliferation of mast cells.
- Mutations of the c-kit receptor, leading to uncontrolled stimulation of the receptor, is a cause for the disease.
Genetics
Genes involved in the pathogenesis of mast cell tumor include: The following genes are involved in the pathogenesis of mast cell tumor:
- KIT
- RAS
- JAK2
- TET2
- DNMT3A
- ASXL1
- CBI
References
- ↑ Brière C (2002). "Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog". Can Vet J. 43 (8): 620–2. PMID 12170840.
- ↑ Mastocytosis. Dr Alexandra Stanislavsky. Radiopaedia.org 2015. http://radiopaedia.org/articles/mastocytosis Accessed on February 29, 2016