Primary cutaneous follicle centre lymphoma pathophysiology: Difference between revisions

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==Genetics==
===Immunophenotyping===


===Gross Pathology===
BCL2 +/-
BCL6 +/-
CD10 +/-
CD20
CD79A+
Ig negative
 
==Gross Pathology==
{|style="margin: 0 auto;"
{|style="margin: 0 auto;"
| [[File:Primary cutaneous follicle centre lymphoma images.jpg|250px|thumb|upright|Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7.  Accessed on March 01, 2016</ref>]]
| [[File:Primary cutaneous follicle centre lymphoma images.jpg|250px|thumb|upright|Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7.  Accessed on March 01, 2016</ref>]]
|}
|}
===Microscopic Pathology===
==Microscopic Pathology==
{|style="margin: 0 auto;"
{|style="margin: 0 auto;"
| [[File:Primary cutaneous follicle centre lymphoma image 2.jpg|650px|thumb|upright|Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7.  Accessed on March 01, 2016</ref>]]
| [[File:Primary cutaneous follicle centre lymphoma image 2.jpg|650px|thumb|upright|Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7.  Accessed on March 01, 2016</ref>]]

Revision as of 13:30, 2 March 2016

Primary cutaneous follicle centre lymphoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Pathophysiology

Genetics

Immunophenotyping

BCL2 +/- BCL6 +/- CD10 +/- CD20 CD79A+ Ig negative

Gross Pathology

Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).[1]

Microscopic Pathology

Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).[1]



References

  1. ↑ 1.0 1.1 Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7. Accessed on March 01, 2016


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