Primary cutaneous follicle centre lymphoma pathophysiology: Difference between revisions

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==Overview==
==Overview==
==Pathophysiology==
==Pathophysiology==
Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells (centrocytes and centroblasts) with a follicular, follicular and diffuse, or diffuse growth pattern.<ref name=hindawi> Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation. Hindawi. http://www.hindawi.com/journals/crim/2010/296523/.  Accessed on March 02, 2016</ref>]]
Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells (centrocytes and centroblasts) with a follicular, follicular and diffuse, or diffuse growth pattern.<ref name=hindawi> Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation. Hindawi. http://www.hindawi.com/journals/crim/2010/296523/.  Accessed on March 02, 2016</ref>]]On gross pathology,solitary or grouped erythematous [[papules]], [[plaques]] and [[tumor]] lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle center lymphoma. On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle center lymphoma.<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
==Genetics==
==Genetics==
Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:<ref name=cancer.gov> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>
Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:<ref name=cancer.gov> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>
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==Microscopic Pathology==
==Microscopic Pathology==
On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle center lymphoma.<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
{|style="margin: 0 auto;"
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| [[File:Primary cutaneous follicle centre lymphoma image 2.jpg|650px|thumb|upright|Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7.  Accessed on March 01, 2016</ref>]]
| [[File:Primary cutaneous follicle centre lymphoma image 2.jpg|650px|thumb|upright|Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7.  Accessed on March 01, 2016</ref>]]

Revision as of 16:10, 2 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Pathophysiology

Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells (centrocytes and centroblasts) with a follicular, follicular and diffuse, or diffuse growth pattern.[1]]]On gross pathology,solitary or grouped erythematous papules, plaques and tumor lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle center lymphoma. On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle center lymphoma.[2]

Genetics

Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:[3]

  • Amplification of C-REL gene
  • BCL-2 rearrangements

Association

Primary cutaneous follicle center lymphoma (PCFCL) may be associated with:[2]

Gross Pathology

On gross pathology,solitary or grouped erythematous papules, plaques and tumor lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle center lymphoma.[2]

Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).[4]

Microscopic Pathology

On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle center lymphoma.[2]

Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).[4]



References

  1. ↑ Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation. Hindawi. http://www.hindawi.com/journals/crim/2010/296523/. Accessed on March 02, 2016
  2. ↑ 2.0 2.1 2.2 2.3 Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I; et al. (2013). "Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature". Radiat Oncol. 8: 147. doi:10.1186/1748-717X-8-147. PMC 3702489. PMID 23786884.
  3. ↑ Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016
  4. ↑ 4.0 4.1 Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7. Accessed on March 01, 2016


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