Primary cutaneous follicle centre lymphoma pathophysiology: Difference between revisions
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| [[File:Primary cutaneous follicle centre lymphoma image 06.jpg|250px|thumb|upright|The epidermis is preserved, with diffuse and nodular infiltrates of lymphoid cells.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147. Accessed on March 02, 2016</ref>]] | | [[File:Primary cutaneous follicle centre lymphoma image 06.jpg|250px|thumb|upright|The epidermis is preserved, with diffuse and nodular infiltrates of lymphoid cells.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147. Accessed on March 02, 2016</ref>]] | ||
| [[File:Primary cutaneous follicle centre lymphoma image 07.jpg|250px|thumb|upright|The | | [[File:Primary cutaneous follicle centre lymphoma image 07.jpg|250px|thumb|upright|The infiltrate is composed of atypical, medium-sized and focally large lymphatic cells.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147. Accessed on March 02, 2016</ref>]] | ||
| [[File:Primary cutaneous follicle centre lymphoma image 08.jpg|250px|thumb|upright|Immunohistochemical staining for CD20 demonstrates diffusely positive reaction in tumour cells (A: IHC, CD20), coexpressing BCL6 (B: IHC, BCL6).<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147. Accessed on March 02, 2016</ref>]] | |||
| [[File:Primary cutaneous follicle centre lymphoma image 2.jpg|350px|thumb|upright|Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7. Accessed on March 01, 2016</ref>]] | | [[File:Primary cutaneous follicle centre lymphoma image 2.jpg|350px|thumb|upright|Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7. Accessed on March 01, 2016</ref>]] | ||
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Revision as of 17:46, 2 March 2016
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Primary cutaneous follicle centre lymphoma Microchapters |
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Differentiating Primary cutaneous follicle centre lymphoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Primary cutaneous follicle center lymphoma is a tumor of neoplastic follicle centre cells, including centrocytes and variable numbers of centroblasts, with a follicular and diffuse growth pattern that generally presents on the head or trunk. This is the most common type of primary cutaneous B-cell lymphoma.[1] Primary cutaneous follicle center lymphoma (PCFCL) may be associated with borrelia burgdorferi, hepatitis C, and human herpesvirus 8. On gross pathology,solitary or grouped erythematous papules, plaques and tumor lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle center lymphoma. On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle center lymphoma.[2]
Pathophysiology
Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells (centrocytes and centroblasts) with a follicular, follicular and diffuse, or diffuse growth pattern.[3]
Genetics
Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:[1]
- Amplification of C-REL gene
- BCL-2 rearrangements
Association
Primary cutaneous follicle center lymphoma (PCFCL) may be associated with:[2]
Gross Pathology
On gross pathology, solitary or grouped erythematous papules, plaques and tumor lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle center lymphoma.[2]
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Microscopic Pathology
On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle center lymphoma.[2]
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References
- ↑ 1.0 1.1 Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016
- ↑ 2.0 2.1 2.2 2.3 Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I; et al. (2013). "Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature". Radiat Oncol. 8: 147. doi:10.1186/1748-717X-8-147. PMC 3702489. PMID 23786884.
- ↑ Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation. Hindawi. http://www.hindawi.com/journals/crim/2010/296523/. Accessed on March 02, 2016
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7. Accessed on March 01, 2016