Donovanosis pathophysiology: Difference between revisions
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===Transmission=== | ===Transmission=== | ||
*''Klebsiella granulomatis'' may be transmitted through sexual contact. | *''Klebsiella granulomatis'' may be transmitted through sexual contact. | ||
*Although donovanosisis is typically considered a [[sexually transmitted disease]], studies indicate it may also develop through fecal contamination or dermal contact. | *Although donovanosisis is typically considered a [[sexually transmitted disease]], studies indicate it may also develop through fecal [[contamination]] or dermal contact. | ||
*''K. granulomatis'' may also autoinoculate, resulting in multiple lesions that appear to be mirror images of each other.<ref name=" O'Farrell">{{cite journal| author=O'Farrell N| title=Donovanosis. | journal=Sex Transm Infect | year= 2002 | volume= 78 | issue= 6 | pages= 452-7 | pmid=12473810 | doi= | pmc=PMC1758360 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12473810 }} </ref> | *''K. granulomatis'' may also [[Autoinoculation|autoinoculate]], resulting in multiple lesions that appear to be mirror images of each other.<ref name="O'Farrell">{{cite journal| author=O'Farrell N| title=Donovanosis. | journal=Sex Transm Infect | year= 2002 | volume= 78 | issue= 6 | pages= 452-7 | pmid=12473810 | doi= | pmc=PMC1758360 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12473810 }} </ref> | ||
===Pathogenesis=== | ===Pathogenesis=== | ||
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==Microscopic Pathology== | ==Microscopic Pathology== | ||
*Donovan bodies (''K. granulomatis'') are seen within phagosomes or in the cytoplasm of monocytes or histocytes. | *Donovan bodies (''K. granulomatis'') are seen within [[Phagosome|phagosomes]] or in the cytoplasm of [[Monocyte|monocytes]] or [[Histiocyte|histocytes]]. | ||
*Morphology of Donovan bodies: | *Morphology of Donovan bodies: | ||
:*Pleomorphic ranging from coccus to bacillus | :*[[Pleomorphic]] ranging from [[coccus]] to [[bacillus]] | ||
:*1-2 X 0.5-0.7 μm | :*1-2 X 0.5-0.7 μm | ||
:*May or may not be capsulated | :*May or may not be capsulated | ||
:*Non-motile | :*Non-motile | ||
*[[Epidermis]] of lesion borders show a degree of [[hyperplasia]]. | *[[Epidermis]] of lesion borders show a degree of [[hyperplasia]]. | ||
*A dense infiltrate of plasma cells is seen in the [[dermis]].<ref name="Richens">{{cite journal| author=Richens J| title=The diagnosis and treatment of donovanosis (granuloma inguinale). | journal=Genitourin Med | year= 1991 | volume= 67 | issue= 6 | pages= 441-52 | pmid=1774048 | doi= | pmc=PMC1194766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1774048 }} </ref> | *A dense infiltrate of [[Plasma cell|plasma cells]] is seen in the [[dermis]].<ref name="Richens">{{cite journal| author=Richens J| title=The diagnosis and treatment of donovanosis (granuloma inguinale). | journal=Genitourin Med | year= 1991 | volume= 67 | issue= 6 | pages= 441-52 | pmid=1774048 | doi= | pmc=PMC1194766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1774048 }} </ref> | ||
==References== | ==References== | ||
Revision as of 16:10, 4 March 2016
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Donovanosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Donovanosis pathophysiology On the Web |
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American Roentgen Ray Society Images of Donovanosis pathophysiology |
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Risk calculators and risk factors for Donovanosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]; Nate Michalak, B.A.
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Overview
Pathophysiology
Transmission
- Klebsiella granulomatis may be transmitted through sexual contact.
- Although donovanosisis is typically considered a sexually transmitted disease, studies indicate it may also develop through fecal contamination or dermal contact.
- K. granulomatis may also autoinoculate, resulting in multiple lesions that appear to be mirror images of each other.[1]
Pathogenesis
Virulence Factors
Adhesion
Associated Conditions
Microscopic Pathology
- Donovan bodies (K. granulomatis) are seen within phagosomes or in the cytoplasm of monocytes or histocytes.
- Morphology of Donovan bodies:
- Pleomorphic ranging from coccus to bacillus
- 1-2 X 0.5-0.7 μm
- May or may not be capsulated
- Non-motile
- Epidermis of lesion borders show a degree of hyperplasia.
- A dense infiltrate of plasma cells is seen in the dermis.[2]