Mast cell tumor laboratory findings: Difference between revisions

	Mast cell tumor Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Mast Cell Tumor from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
Diagnostic criteria
Staging
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography or Ultrasound
CT Scan
MRI
Biopsy
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Mast cell tumor laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Mast cell tumor laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Mast cell tumor laboratory findings
CDC on Mast cell tumor laboratory findings
Mast cell tumor laboratory findings in the news
Blogs on Mast cell tumor laboratory findings
Directions to Hospitals Treating Mast cell tumor
Risk calculators and risk factors for Mast cell tumor laboratory findings

Revision as of 20:16, 4 March 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Following flow chart illustrates the diagnostic pathway of mast cell tumor:^[1]

Skin lesions or suggestive clinical features

Serum Tryptase

Complete blood count

Complete metabolic panel

Normal complete blood count

Serum tryptase ≤ 100ng/ml

Abnormal complete blood cell count Serum tryptase > 100 ng/ml

Cutaneous mastocytosis

Bone marrow: biopsy and aspiration

Negative findings:

Other diagnosis

Positive findings: Systemic mastocytosis

Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis.
In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels.
Additionally, tryptase levels in SM are assumed to correlate closely with the cumulative mast cell burden and multiorgan involvement

Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine

↑ Ferrante, Giuliana; Scavone, Valeria; Muscia, Maria; Adrignola, Emilia; Corsello, Giovanni; Passalacqua, Giovanni; La Grutta, Stefania (2015). "The care pathway for children with urticaria, angioedema, mastocytosis". World Allergy Organization Journal. 8 (1): 5. doi:10.1186/s40413-014-0052-x. ISSN 1939-4551.
↑ Ozdemir, Didem; Dagdelen, Selcuk; Erbas, Tomris; Agbaht, Kemal; Serefhanoglu, Songul; Aksu, Salih; Ersoy-Evans, Sibel (2010). "Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report". Case Reports in Medicine. 2010: 1–4. doi:10.1155/2010/782595. ISSN 1687-9627.

@@ Line 29: / Line 29: @@
 {{familytree/end}}
+===Laboratory findings===
-The diagnosis of systemic mastocytosis is established by demonstrating mast cell infiltration in an involved tissue, particularly the bone marrow, using special staining techniques or flow cytometry, but the measurement of serum tryptase is a good screening test, since almost all patients with systemic mastocytosis have serum tryptase levels exceeding 20 ng/mL.<ref name="KoenigMorel2008">{{cite journal|last1=Koenig|first1=Martial|last2=Morel|first2=Jérôme|last3=Reynaud|first3=Jacqueline|last4=Varvat|first4=Cécile|last5=Cathébras|first5=Pascal|title=An unusual cause of spontaneous bleeding in the intensive care unit – mastocytosis: a case report|journal=Cases Journal|volume=1|issue=1|year=2008|pages=100|issn=1757-1626|doi=10.1186/1757-1626-1-100}}</ref>
 *[[Complete blood count]]
 :*[[Eosinophilia]]