Mast cell tumor laboratory findings: Difference between revisions
Jump to navigation
Jump to search
| Line 31: | Line 31: | ||
===Laboratory findings=== | ===Laboratory findings=== | ||
*[[Complete blood count]] | *[[Complete blood count]] | ||
:*[[Anemia]] | |||
:*[[Eosinophilia]] | :*[[Eosinophilia]] | ||
:*[[Thrombocytopenia]] | :*[[Thrombocytopenia]] | ||
Revision as of 20:50, 4 March 2016
|
Mast cell tumor Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Mast cell tumor laboratory findings On the Web |
|
American Roentgen Ray Society Images of Mast cell tumor laboratory findings |
|
Risk calculators and risk factors for Mast cell tumor laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Diagnostic pathway of mastocytosis
Following flow chart illustrates the diagnostic pathway of mast cell tumor:[1]
Skin lesions or suggestive clinical features | |||||||||||||||||||||||||||||||||||||
Serum Tryptase
Complete blood count Complete metabolic panel | |||||||||||||||||||||||||||||||||||||
Normal complete blood count
Serum tryptase ≤ 100ng/ml | Abnormal complete blood cell count
Serum tryptase > 100 ng/ml | ||||||||||||||||||||||||||||||||||||
Cutaneous mastocytosis
| Bone marrow: biopsy and aspiration
| ||||||||||||||||||||||||||||||||||||
Negative findings:
Other diagnosis | Positive findings: Systemic mastocytosis | ||||||||||||||||||||||||||||||||||||
Laboratory findings
- Tryptase which is stored almost exclusively within the secretory granules of mast cells is the most widely used marker of mastocytosis.
- In healthy individuals, serum tryptase levels range between <1 and 15 ng/mL; however, mast cell activation causes increased tryptase levels.
- Additionally, tryptase levels in SM are assumed to correlate closely with the cumulative mast cell burden and multiorgan involvement
- Plasma and urinary histamine
- Chronically elevated plasma and urinary histamine levels and its metabolite N-methylhistamine
- Elevated in a blood sample obtained immediately after attack
References
- ↑ Ferrante, Giuliana; Scavone, Valeria; Muscia, Maria; Adrignola, Emilia; Corsello, Giovanni; Passalacqua, Giovanni; La Grutta, Stefania (2015). "The care pathway for children with urticaria, angioedema, mastocytosis". World Allergy Organization Journal. 8 (1): 5. doi:10.1186/s40413-014-0052-x. ISSN 1939-4551.
- ↑ Ozdemir, Didem; Dagdelen, Selcuk; Erbas, Tomris; Agbaht, Kemal; Serefhanoglu, Songul; Aksu, Salih; Ersoy-Evans, Sibel (2010). "Hypotension, Syncope, and Fever in Systemic Mastocytosis without Skin Infiltration and Rapid Response to Corticosteroid and Cyclosporin: A Case Report". Case Reports in Medicine. 2010: 1–4. doi:10.1155/2010/782595. ISSN 1687-9627.