Myelofibrosis laboratory tests: Difference between revisions
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==Laboratory Tests== | ==Laboratory Tests== | ||
Diagnosis | Laboratory findings consistent with the diagnosis of myelofibrosis include:<ref name=wikidiagn1osismf1>Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016</ref> | ||
===Complete Blood Count=== | |||
*[[anemia|Decreased red blood cells]] | |||
*[[Hemoglobin|Reduced hemoglobin]] | |||
*[[thrombocytopenia|Decreased platelets]] | |||
*[[leukopenia|Decreased white blood cells]] | |||
===Peripheral Blood Smear=== | |||
*[[Normochromic]] normocytic [[anemia]] | |||
*Red cell [[poikilocytosis]] on blood film (tear-drop shaped RBCs) | |||
* JAK 2 mutation on Val 617 Phe locus in 50% | * JAK 2 mutation on Val 617 Phe locus in 50% | ||
* Raised levels of [[lactate dehydrogenase]] | * Raised levels of [[lactate dehydrogenase]] | ||
Revision as of 16:01, 8 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory Tests
Laboratory findings consistent with the diagnosis of myelofibrosis include:[1]
Complete Blood Count
Peripheral Blood Smear
- Normochromic normocytic anemia
- Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
- JAK 2 mutation on Val 617 Phe locus in 50%
- Raised levels of lactate dehydrogenase
- Raised neutrophil alkaline phosphatase score
TB testing
The patient with the myelofibrosis should be tested for Tuberculosis even if the patient doesn't manifest the symptoms of TB. There is strong evidence of myelofibrois improvement with the antituberculous treatment.
References
- ↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016