Myelofibrosis laboratory tests: Difference between revisions
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===Complete Metabolic Panel=== | ===Complete Metabolic Panel=== | ||
*Raised levels of [[lactate dehydrogenase]] | *Raised levels of [[lactate dehydrogenase]] | ||
===JAK2 Mutation Analysis Testing=== | ===JAK2 Mutation Analysis Testing=== | ||
Revision as of 16:47, 8 March 2016
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Myelofibrosis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory Tests
Laboratory findings consistent with the diagnosis of myelofibrosis include:[1]
Complete Blood Count
Peripheral Blood Smear
- Normochromic normocytic anemia
- Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
- Nucleated red blood cells
- Presence of nucleated red blood cells suggests that immature cells are being released into the bloodstream in response to a very high demand for the bone marrow to produce new red blood cells.
Complete Metabolic Panel
- Raised levels of lactate dehydrogenase
JAK2 Mutation Analysis Testing
- JAK2 mutation on Val 617 Phe locus in 50%
===Leukocyte Alkaline Phosphatase Test (LAP Test)
- Raised leukocyte alkaline phosphatase score
References
- ↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016