Myelofibrosis laboratory tests: Difference between revisions
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==Laboratory Tests== | ==Laboratory Tests== | ||
Laboratory findings consistent with the diagnosis of myelofibrosis include:<ref name=wikidiagn1osismf1>Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016</ref> | Laboratory findings consistent with the diagnosis of myelofibrosis include:<ref name=wikidiagn1osismf1>Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016</ref><ref name=cancercaidiopathicmyelofibrosisdx1>Diagnosis of idiopathic myelofibrosis. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/idiopathic-myelofibrosis/?region=on. Accessed on March 9, 2016</ref> | ||
===Complete Blood Count=== | ===Complete Blood Count=== | ||
Revision as of 14:53, 9 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory Tests
Laboratory findings consistent with the diagnosis of myelofibrosis include:[1][2]
Complete Blood Count
Peripheral Blood Smear
- Normochromic normocytic anemia
- Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
- Nucleated red blood cells
- Presence of nucleated red blood cells suggests that immature cells are being released into the bloodstream in response to a very high demand for the bone marrow to produce new red blood cells.
Complete Metabolic Panel
- Raised levels of lactate dehydrogenase
JAK2 Mutation Analysis Testing
- JAK2 mutation on Val 617 Phe locus in 50%
- Reverse transcriptase polymerase chain reaction (RT-PCR) may be performed to observe the JAK2 mutation.
Leukocyte Alkaline Phosphatase Test (LAP Test)
References
- ↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016
- ↑ Diagnosis of idiopathic myelofibrosis. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/idiopathic-myelofibrosis/?region=on. Accessed on March 9, 2016