Intravascular large B-cell lymphoma: Difference between revisions

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{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{AS}}


{{SK}} Intravascular large B cell lymphoma; intravascular large cell lymphoma
{{SK}}  
== Overview ==


==Classification==
Intravascular large B-cell lymphoma may be classified into either


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== Pathophysiology==
===Microscopic Pathology===
==Causes==
There are no established causes for intravascular large B-cell lymphoma.
==Differentiating type page name here from other Diseases==
Intravascular large B-cell lymphoma must be differentiated from other diseases such as:
== Epidemiology and Demographics ==
===Age===
===Gender===
== Risk Factors ==
There are no established risk factors for intravascular large B-cell lymphoma.
== Screening ==
According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for intravascular large B-cell lymphoma.<ref name=uspreventive> Recommendations. U.S Preventive Services Task Force.  Accessed on March 9, 2016</ref>
== Natural History, Complications and Prognosis==
* People with this type of lymphoma can also develop a very serious condition where certain parts of the immune system are activated (hemophagocytic syndrome).<ref name=seer.cancer.gov>Intravascular large B-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd54a7/. Accessed on March 09, 2016 </ref>
* Hemophagocytic syndrome causes:
:* [[Fever]]
:* Enlarged liver and spleen ([[hepatosplenomegaly]])
:* A lower number of red blood cells, white blood cells and platelets in the blood ([[pancytopenia]])
== Diagnosis ==
=== Symptoms ===
Symptoms of the intravascular large B-cell lymphoma include:<ref name=seer.cancer.gov>Intravascular large B-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd54a7/. Accessed on March 09, 2016 </ref>
* [[Fever]]
* [[Weight loss]]
* [[Night sweats]]
* Painless swellings in the neck, axilla, groin, thorax, and abdomen
* Pain in the chest, abdomen, or bones
=== Physical Examination ===
====Vitals====
* [[Fever]] is often present
====Skin====
* Skin rash
====HEENT====
* [[Lymphadenopathy|Cervical lymphadenopathy]]
====Thorax====
* Thoracic masses suggestive of [[Lymphadenopathy|central lymphadenopathy]]
====Abdomen====
* [[Abdominal mass]]es suggestive of [[Lymphadenopathy|central lymphadenopathy]]
* [[Hepatosplenomegaly]]
====Extremities====
* [[Lymphadenopathy|Peripheral lymphadenopathy]]
===Laboratory Findings ===
Laboratory tests for intravascular large B-cell lymphoma include:<ref name=seer.cancer.gov>Intravascular large B-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd54a7/. Accessed on March 09, 2016 </ref>
* [[Complete blood count]] (CBC): [[pancytopenia]]
* Blood chemistry studies:
* Cytogenetic analysis
* [[Flow cytometry]]
* [[Immunohistochemistry]]
* [[Immunophenotyping]]
====Biopsy====
Lymph node biopsy is diagnostic of intravascular large B-cell lymphoma.
==== Other Imaging Findings ====
[[CT]], [[MRI]], and [[PET]] scan may be helpful in the diagnosis of intravascular large B-cell lymphoma.
==Treatment==
===Medical Therapy===
==References==
{{Reflist|2}}
[[Category:Disease]]
[[Category:Oncology]]
==Related Chapters==
==Related Chapters==
* [[Richter's transformation]]
* [[Richter's transformation]]

Revision as of 16:54, 9 March 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Synonyms and keywords:

Overview

Classification

Intravascular large B-cell lymphoma may be classified into either

Intravascular large B-cell lymphoma classification
Name Description

Pathophysiology

Microscopic Pathology

Causes

There are no established causes for intravascular large B-cell lymphoma.

Differentiating type page name here from other Diseases

Intravascular large B-cell lymphoma must be differentiated from other diseases such as:


Epidemiology and Demographics

Age

Gender

Risk Factors

There are no established risk factors for intravascular large B-cell lymphoma.

Screening

According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for intravascular large B-cell lymphoma.[1]

Natural History, Complications and Prognosis

  • People with this type of lymphoma can also develop a very serious condition where certain parts of the immune system are activated (hemophagocytic syndrome).[2]
  • Hemophagocytic syndrome causes:


Diagnosis

Symptoms

Symptoms of the intravascular large B-cell lymphoma include:[2]

Physical Examination

Vitals

Skin

  • Skin rash

HEENT

Thorax

Abdomen

Extremities

Laboratory Findings

Laboratory tests for intravascular large B-cell lymphoma include:[2]

Biopsy

Lymph node biopsy is diagnostic of intravascular large B-cell lymphoma.

Other Imaging Findings

CT, MRI, and PET scan may be helpful in the diagnosis of intravascular large B-cell lymphoma.

Treatment

Medical Therapy

References

  1. ↑ Recommendations. U.S Preventive Services Task Force. Accessed on March 9, 2016
  2. ↑ 2.0 2.1 2.2 Intravascular large B-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd54a7/. Accessed on March 09, 2016

Related Chapters



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