Myelofibrosis differential diagnosis: Difference between revisions

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Revision as of 15:01, 11 March 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]

Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis. They are tabulated below.^[1]^[2]


Type of diseases	Diseases

Hematological causes	Sickle cell disease
Metabolic bone disorders	Hyperthyroidism Hypoparathyroidism Renal osteodystrophy
Congenital	Sclerosing bone dysplasia Osteopetrosis Pyknodysostosis
Malignancy	Lymphoma: infiltration Leukaemia: infiltration Osteoblastic metastases prostate cancer breast cancer
Other	Paget disease Fluorosis Mastocytosis Hepatitis C associated osteosclerosis (HCAO)

↑ Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016
↑ Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016

@@ Line 18: / Line 18: @@
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|Metabolic bone disorders
-| style="padding: 5px 5px; background: #F5F5F5;" |[[Hyperthyroidism]]<br>
+| style="padding: 5px 5px; background: #F5F5F5;" |[[Hyperthyroidism]]<br>[[Hypoparathyroidism]]<br>[[Renal osteodystrophy]]
-[[Hypoparathyroidism]]<br>
-[[Renal osteodystrophy]]
 |-
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Congenital
-| style="padding: 5px 5px; background: #F5F5F5;" |[[dysplasia|Sclerosing bone dysplasia]]<br>
+| style="padding: 5px 5px; background: #F5F5F5;" |[[dysplasia|Sclerosing bone dysplasia]]<br>[[Osteopetrosis]]<br>[[Pyknodysostosis]]
-[[Osteopetrosis]]<br>
-[[Pyknodysostosis]]
 |-
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Malignancy
-| style="padding: 5px 5px; background: #F5F5F5;" |[[Lymphoma]]: infiltration<br>
+| style="padding: 5px 5px; background: #F5F5F5;" |[[Lymphoma]]: infiltration<br>[[Leukaemia]]: infiltration<br>[[bone metastasis|Osteoblastic metastases]]
-[[Leukaemia]]: infiltration<br>
-[[bone metastasis|Osteoblastic metastases]]<br>
 *[[prostate cancer]]
 *[[breast cancer]]