Myelofibrosis differential diagnosis: Difference between revisions

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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Other
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Other
| style="padding: 5px 5px; background: #F5F5F5;" |[[Paget disease]]<br>[[Fluorosis]]<br>[[Mastocytosis]]<br>[[osteosclerosis|Hepatitis C associated osteosclerosis]] (HCAO)
| style="padding: 5px 5px; background: #F5F5F5;" |[[Paget disease]]<br>[[Fluorosis]]<br>[[Mastocytosis]]<br>[[osteosclerosis|Hepatitis C associated osteosclerosis]] (HCAO)
|}
Myelofibrosis must be differentiated from other diseases that cause [[splenomegaly]]. They are tabulated below.<ref name=myelofibrosisdiffdiagnsosiseradio1>Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016</ref><ref name=splenomegalydiffdiagnosisradio1>Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/splenomegaly. Accessed on March 11, 2016</ref>
{| style="border: 0px; font-size: 90%; margin: 3px; width:650px"
|valign=top|
|+
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Type of diseases}}
! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Diseases}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Hematological causes
| style="padding: 5px 5px; background: #F5F5F5;" |Anaemia
*[[Sickle cell disease]]
*[[Thalassemia]]
*[[Hereditary spherocytosis]]
*[[Pyruvate kinase deficiency]]
*[[Thrombotic thrombocytopaenic purpura]] (TTP)<br>Neoplastic/proliferative/redistribution of hematopoesis
*[[Leukemia]] (especially [[CML]]*)
*[[Polycythaemia rubra vera]] (PRV) *
*[[Waldenström macroglobulinaemia]]
*[[Extramedullary haematopoiesis]]
*[[Osteopetrosis]]
*[[Idiopathic hypereosinophilic syndrome]]
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|Hemodynamic
| style="padding: 5px 5px; background: #F5F5F5;" |[[Cirrhosis]]: [[portal hypertension]]<br>Congestive splenomegaly ([[Banti syndrome]])<br>[[Splenic vein obstruction]]<br>[[Portal vein obstruction]]<br>[[Right heart failure]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Infection
| style="padding: 5px 5px; background: #F5F5F5;" |Viral
*[[EBV]] (infectious mononucleosis) - (common)
*[[AIDS]]
*[[CMV]]
*[[Herpes simplex virus]]
*[[Rubella]]<br>Bacterial
*[[Tuberculosis]] (miliary)
*[[Tularemia]]
*[[Subacute bacterial endocarditis]]
*[[Typhoid fever]]
*[[Brucellosis]]
*[[Syphilis]]
*[[Abscess]]<br>Fungal
*[[Histoplasmosis]] (common)
*[[Candidiasis]]<br>Parasitic disease
*[[Malaria]]*
*[[Schistosomiasis]]
*[[Hydatid disease]]
*[[Leishmaniasis]] (kala-azar)
*[[Rickettsial]]
:*[[Typhus]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Storage diseases/metabolic/infiltrative disorders
| style="padding: 5px 5px; background: #F5F5F5;" |[[Gaucher disease]]<br>[[Glycogen storage disease]]<br>[[Mucopolysaccharidoses]]<br>[[Niemann-Pick disease]]<br>[[Hemochromatosis]]<br>[[Amyloidosis]]<br>[[Porphyria]]<br>[[Sarcoidosis]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Neoplastic
| style="padding: 5px 5px; background: #F5F5F5;" |[[Lymphoma]] (common)<br>[[Metastases]] (breast, lung, colon, ovary, melanoma)<br>[[Hemangioma]]<br>[[Lymphangioma]]<br>[[Angiosarcoma]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Trauma
| style="padding: 5px 5px; background: #F5F5F5;" |[[Hematoma]]<br>[[Pseudocyst]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Connective tissue disorders
| style="padding: 5px 5px; background: #F5F5F5;" |[[Rheumatoid arthritis]]
*[[Felty syndrome]]
*[[Juvenile rheumatoid arthritis]] (JRA)
*[[Still's disease]]<br>[[Systemic lupus erythematosus]] (SLE)
|}
|}


Revision as of 15:23, 11 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]

Overview

Differentiating Myelofibrosis from other Diseases

Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis. They are tabulated below.[1][2]

Type of diseases Diseases
Hematological causes Sickle cell disease
Metabolic bone disorders Hyperthyroidism
Hypoparathyroidism
Renal osteodystrophy
Congenital Sclerosing bone dysplasia
Osteopetrosis
Pyknodysostosis
Malignancy Lymphoma: infiltration
Leukaemia: infiltration
Osteoblastic metastases
Other Paget disease
Fluorosis
Mastocytosis
Hepatitis C associated osteosclerosis (HCAO)

Myelofibrosis must be differentiated from other diseases that cause splenomegaly. They are tabulated below.[1][3]

Type of diseases Diseases
Hematological causes Anaemia
Hemodynamic Cirrhosis: portal hypertension
Congestive splenomegaly (Banti syndrome)
Splenic vein obstruction
Portal vein obstruction
Right heart failure
Infection Viral
Storage diseases/metabolic/infiltrative disorders Gaucher disease
Glycogen storage disease
Mucopolysaccharidoses
Niemann-Pick disease
Hemochromatosis
Amyloidosis
Porphyria
Sarcoidosis
Neoplastic Lymphoma (common)
Metastases (breast, lung, colon, ovary, melanoma)
Hemangioma
Lymphangioma
Angiosarcoma
Trauma Hematoma
Pseudocyst
Connective tissue disorders Rheumatoid arthritis

References

  1. ↑ 1.0 1.1 Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016
  2. ↑ Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016
  3. ↑ Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/splenomegaly. Accessed on March 11, 2016

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