Retinitis causes: Difference between revisions
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==Overview== | ==Overview== | ||
Retinitis may be caused by multiple infectious agents including cytomegalovirus, toxoplasmosis, and candida. Retinitis Pigmentosa is classified as a genetic eye disease which occurs as a result of an inherited defect. <ref name= "US GEN"> Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.genome.gov/13514348 </ref> | Retinitis may be caused by multiple infectious agents including cytomegalovirus, toxoplasmosis, tuberculosis, syphilis, and candida. Retinitis Pigmentosa is classified as a genetic eye disease which occurs as a result of an inherited defect. <ref name="US GEN">Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.genome.gov/13514348 </ref> | ||
==Causes of Retinitis== | ==Causes of Retinitis== | ||
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====Retinitis Pigmentosa==== | ====Retinitis Pigmentosa==== | ||
*Retinitis Pigmentosa is classified as a genetic eye disease, inherited from either one or both of a patient's parents. <ref name= "US LIB"> Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/001029.htm </ref> | *Retinitis Pigmentosa is classified as a genetic eye disease, inherited from either one or both of a patient's parents. <ref name="US LIB">Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/001029.htm </ref> | ||
*The disease is a result of genetic defects in one of 50 genes required for the proper creation of photoreceptor proteins. <ref name= "US GEN"> Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.genome.gov/13514348 </ref> | *The disease is a result of genetic defects in one of 50 genes required for the proper creation of photoreceptor proteins. <ref name="US GEN">Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.genome.gov/13514348 </ref> | ||
*Generally the genetic disorder is linked to the inheritance of a recessive gene contributed by both parents. <ref name= "US LIB"> Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/001029.htm </ref> | *Generally the genetic disorder is linked to the inheritance of a recessive gene contributed by both parents. <ref name="US LIB">Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/001029.htm </ref> | ||
*Other cases have been linked to the inheritance of a dominant gene, defects of the X chromosome, and newly formed mutations caused by diseases. | *Other cases have been linked to the inheritance of a dominant gene, defects of the X chromosome, and newly formed mutations caused by diseases. | ||
*Progression of RP causes photoreceptor, cellular breakdown, both rods and cones. | *Progression of RP causes photoreceptor, cellular breakdown, both rods and cones. | ||
*Ultimately, the progressive breakdown of photoreceptors leads to restricted vision or permanent loss of vision. <ref name= "US LIB"> Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/001029.htm </ref> | *Ultimately, the progressive breakdown of photoreceptors leads to restricted vision or permanent loss of vision. <ref name="US LIB">Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/001029.htm </ref> | ||
===Infectious Agents=== | ===Infectious Agents=== | ||
Revision as of 19:45, 6 April 2016
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Overview
Retinitis may be caused by multiple infectious agents including cytomegalovirus, toxoplasmosis, tuberculosis, syphilis, and candida. Retinitis Pigmentosa is classified as a genetic eye disease which occurs as a result of an inherited defect. [1]
Causes of Retinitis
Genetic
Retinitis Pigmentosa
- Retinitis Pigmentosa is classified as a genetic eye disease, inherited from either one or both of a patient's parents. [2]
- The disease is a result of genetic defects in one of 50 genes required for the proper creation of photoreceptor proteins. [1]
- Generally the genetic disorder is linked to the inheritance of a recessive gene contributed by both parents. [2]
- Other cases have been linked to the inheritance of a dominant gene, defects of the X chromosome, and newly formed mutations caused by diseases.
- Progression of RP causes photoreceptor, cellular breakdown, both rods and cones.
- Ultimately, the progressive breakdown of photoreceptors leads to restricted vision or permanent loss of vision. [2]
Infectious Agents
Cytomegalovirus Retinitis
- Cytomegalovirus Retinitis is a result of viral, herpes infection of the retina.
- Highly prevalent as a cause of blindness within the AIDS infected population.
Syphilis
- Retinitis resulting from a syphilitic infection is commonly referred to as a ocular syphilis.
- The infection persists as syphilitic spirochetes, Treponema pallidum, invade or cause allergic reactions within the surrounding tissue.
Endogenous Fungal Infections
- Two types of retina infections may occur depending on a mode of fungal infection. These two types our outlined as endogenous or exogenous.
- Endogenous fungal retinitis is primarily a result of a disseminated fungal infection.
- Exogenous fungal infections primarily occur as a result of a recent event such as physical injury or surgery.
- Exogenous fungal infections are usually a result of Candidal retinitis. An infection commonly associated with candida chorioretinitis.
- Candidas chorioretinitis is typically caused by the species Candida albicans.
Tuberculosis
- Extrapulmonary clinical manifestations of tuberculosis include intraocular caseating granulomas.
- Infection of the retina is associated with the spread of the tuberculosis causing bacterial agents.
- Common presentation of tuberculosis in the retina appears as multiple choroidal tubercles.
- These tubercles are best defined as minor nodules with a grayish appearance.
Toxoplasma gondii
References
- ↑ 1.0 1.1 Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.genome.gov/13514348
- ↑ 2.0 2.1 2.2 Retinitis Pigmentosa. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/001029.htm