Retinitis imaging findings: Difference between revisions
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==Overview== | ==Overview== | ||
The optical coherence tomography (OCT) and the fundus autofluorescence (FAF) techniques are most often used when diagnosing a genetic variation of retinitis. OCT may be used to acquire ''in situ'' retinal imaging for diagnosis of ocular diseases. FAF imaging is a non-invasive technique, dependent on the presence of lipofuscin pigments (lipofuscin is a by-product of lysosomes during the normal process of photoreceptor degradation.) | The [[optical coherence tomography]] (OCT) and the [[fundus autofluorescence]] (FAF) techniques are most often used when [[Diagnose|diagnosing]] a [[genetic variation]] of retinitis. OCT may be used to acquire ''[[in situ]]'' retinal imaging for diagnosis of [[Ocular disease|ocular diseases]]. FAF imaging is a non-invasive technique, dependent on the presence of [[lipofuscin]] [[pigments]] [[Lipofuscin|(lipofuscin]] is a by-product of [[lysosomes]] during the normal process of [[Photoreceptor cells|photoreceptor]] degradation.) | ||
==Imaging Findings== | ==Imaging Findings== | ||
===Retinitis pigmentosa=== | ===Retinitis pigmentosa=== | ||
====Optical Coherence Tomography==== | ====Optical Coherence Tomography==== | ||
*An imaging technique used to acquire ''in situ'' retinal imaging for diagnosis of ocular diseases. | *An imaging technique used to acquire ''[[in situ]]'' retinal imaging for diagnosis of [[Eye disease|ocular diseases]]. | ||
*Recent developments have revealed a highly reflective line, identified as the photoreceptor inner and outer segment (IS/OS); crucial for the diagnosis of retinitis pigmentosa. | *Recent developments have revealed a highly reflective line, identified as the [[Photoreceptor cells|photoreceptor]] inner and outer segment (IS/OS); crucial for the [[Diagnose|diagnosis]] of retinitis pigmentosa. | ||
*The line is an indicator of a normal alignment of the outer segment's membranous discs in the photoreceptor. | *The line is an indicator of a normal alignment of the outer segment's membranous discs in the [[Photoreceptor cells|photoreceptor]]. | ||
*The OCT should therefore display a continuous IS/OS line. This line serves as an indicator of good vision, as well as recovery from an invasive, intraocular surgery.<ref name= "OCT"> Diagnostic imaging in patients with retinitis pigmentosa. Mitamura Y, Mitamura-aizawa S, Nagasawa T, Katome T, Eguchi H, Naito T. Diagnostic imaging in patients with retinitis pigmentosa. J Med Invest. 2012;59(1-2):1-11. http://www.ncbi.nlm.nih.gov/pubmed/22449988. Accessed April 19, 2016. </ref> | *The [[Optical coherence tomography|OCT]] should therefore display a continuous IS/OS line. This line serves as an indicator of good vision, as well as recovery from an invasive, intraocular surgery.<ref name="OCT">Diagnostic imaging in patients with retinitis pigmentosa. Mitamura Y, Mitamura-aizawa S, Nagasawa T, Katome T, Eguchi H, Naito T. Diagnostic imaging in patients with retinitis pigmentosa. J Med Invest. 2012;59(1-2):1-11. http://www.ncbi.nlm.nih.gov/pubmed/22449988. Accessed April 19, 2016. </ref> | ||
====Fundus Autofluorescence==== | ====Fundus Autofluorescence==== | ||
*Noninvasive method of diagnosing retinal disease. | *Noninvasive method of [[Diagnosis|diagnosing]] [[retinal disease]]. | ||
*FAF imaging is dependent on the presence of lipofuscin pigments (lipofuscin is a by-product of lysosomes during the normal process of photoreceptor degradation.) | *FAF imaging is dependent on the presence of [[lipofuscin]] [[pigments]] ([[lipofuscin]] is a by-product of [[Lysosome|lysosomes]] during the normal process of [[Photoreceptor cells|photoreceptor]] degradation.) | ||
*Identification of normal levels of lipofuscin indicates normal function of photoreceptor cells. | *Identification of normal levels of [[lipofuscin]] indicates normal function of [[Photoreceptor cells|photoreceptor]] cells. | ||
*Correct functioning of this cycle is dependent on normal function of retinal pigment epithelium and therefore may be used as a diagnostic tool for retinitis pigmentosa. | *Correct functioning of this cycle is dependent on normal function of [[retinal pigment epithelium]] and therefore may be used as a diagnostic tool for retinitis pigmentosa. | ||
*More than half of patients suffering from retinitis pigmentosa will display a high density of FAF in the form of a parafoveal ring.<ref name= "OCT"> Diagnostic imaging in patients with retinitis pigmentosa. Mitamura Y, Mitamura-aizawa S, Nagasawa T, Katome T, Eguchi H, Naito T. Diagnostic imaging in patients with retinitis pigmentosa. J Med Invest. 2012;59(1-2):1-11. http://www.ncbi.nlm.nih.gov/pubmed/22449988. Accessed April 19, 2016. </ref> | *More than half of patients suffering from retinitis pigmentosa will display a high density of FAF in the form of a parafoveal ring.<ref name="OCT">Diagnostic imaging in patients with retinitis pigmentosa. Mitamura Y, Mitamura-aizawa S, Nagasawa T, Katome T, Eguchi H, Naito T. Diagnostic imaging in patients with retinitis pigmentosa. J Med Invest. 2012;59(1-2):1-11. http://www.ncbi.nlm.nih.gov/pubmed/22449988. Accessed April 19, 2016. </ref> | ||
==References== | ==References== | ||
Revision as of 19:58, 19 April 2016
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Overview
The optical coherence tomography (OCT) and the fundus autofluorescence (FAF) techniques are most often used when diagnosing a genetic variation of retinitis. OCT may be used to acquire in situ retinal imaging for diagnosis of ocular diseases. FAF imaging is a non-invasive technique, dependent on the presence of lipofuscin pigments (lipofuscin is a by-product of lysosomes during the normal process of photoreceptor degradation.)
Imaging Findings
Retinitis pigmentosa
Optical Coherence Tomography
- An imaging technique used to acquire in situ retinal imaging for diagnosis of ocular diseases.
- Recent developments have revealed a highly reflective line, identified as the photoreceptor inner and outer segment (IS/OS); crucial for the diagnosis of retinitis pigmentosa.
- The line is an indicator of a normal alignment of the outer segment's membranous discs in the photoreceptor.
- The OCT should therefore display a continuous IS/OS line. This line serves as an indicator of good vision, as well as recovery from an invasive, intraocular surgery.[1]
Fundus Autofluorescence
- Noninvasive method of diagnosing retinal disease.
- FAF imaging is dependent on the presence of lipofuscin pigments (lipofuscin is a by-product of lysosomes during the normal process of photoreceptor degradation.)
- Identification of normal levels of lipofuscin indicates normal function of photoreceptor cells.
- Correct functioning of this cycle is dependent on normal function of retinal pigment epithelium and therefore may be used as a diagnostic tool for retinitis pigmentosa.
- More than half of patients suffering from retinitis pigmentosa will display a high density of FAF in the form of a parafoveal ring.[1]
References
- ↑ 1.0 1.1 Diagnostic imaging in patients with retinitis pigmentosa. Mitamura Y, Mitamura-aizawa S, Nagasawa T, Katome T, Eguchi H, Naito T. Diagnostic imaging in patients with retinitis pigmentosa. J Med Invest. 2012;59(1-2):1-11. http://www.ncbi.nlm.nih.gov/pubmed/22449988. Accessed April 19, 2016.