Angiosarcoma

WikiDoc Resources for Angiosarcoma
Articles
Most recent articles on Angiosarcoma Most cited articles on Angiosarcoma Review articles on Angiosarcoma Articles on Angiosarcoma in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Angiosarcoma Images of Angiosarcoma Photos of Angiosarcoma Podcasts & MP3s on Angiosarcoma Videos on Angiosarcoma
Evidence Based Medicine
Cochrane Collaboration on Angiosarcoma Bandolier on Angiosarcoma TRIP on Angiosarcoma
Clinical Trials
Ongoing Trials on Angiosarcoma at Clinical Trials.gov Trial results on Angiosarcoma Clinical Trials on Angiosarcoma at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Angiosarcoma NICE Guidance on Angiosarcoma NHS PRODIGY Guidance FDA on Angiosarcoma CDC on Angiosarcoma
Books
Books on Angiosarcoma
News
Angiosarcoma in the news Be alerted to news on Angiosarcoma News trends on Angiosarcoma
Commentary
Blogs on Angiosarcoma
Definitions
Definitions of Angiosarcoma
Patient Resources / Community
Patient resources on Angiosarcoma Discussion groups on Angiosarcoma Patient Handouts on Angiosarcoma Directions to Hospitals Treating Angiosarcoma Risk calculators and risk factors for Angiosarcoma
Healthcare Provider Resources
Symptoms of Angiosarcoma Causes & Risk Factors for Angiosarcoma Diagnostic studies for Angiosarcoma Treatment of Angiosarcoma
Continuing Medical Education (CME)
CME Programs on Angiosarcoma
International
Angiosarcoma en Espanol Angiosarcoma en Francais
Business
Angiosarcoma in the Marketplace Patents on Angiosarcoma
Experimental / Informatics
List of terms related to Angiosarcoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Synonyms and keywords: Hemangiosarcoma; Pulmonary angiosarcoma; Vascular sarcoma

Overview

Angiosarcoma is a rare malignant vascular neoplasm of endothelial-type cells that line vessel walls.

Historical Perspective

• Angiosarcoma was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].

Classification

• Angiosarcoma may be classified according to [classification method] into [number] subtypes/groups:

• Other variants of angiosarcoma include [disease subtype 1], [disease subtype 2], and [disease subtype 3].

Pathophysiology

• The pathogenesis of angiosarcoma is characterized by [feature1], [feature2], and [feature3].
• The [gene name] gene/Mutation in [gene name] has been associated with the development of angiosarcoma, involving the [molecular pathway] pathway.
• On gross pathology, characteristic findings of angiosarcoma, may include:
• On microscopic histopathological analysis, characteristic findings of angiosarcoma, may include:

Causes

• Common causes of angiosarcoma may include:

Differentiating angiosarcoma from other Diseases

• Angiosarcoma must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:

• [Differential dx1]
• [Differential dx2]
• [Differential dx3]

Epidemiology and Demographics

• The prevalence of angiosarcoma is approximately [number or range] per 100,000 individuals worldwide.
• In [year], the incidence of angiosarcoma was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

• Patients of all age groups may develop angiosarcoma.

• Angiosarcoma is more commonly observed among patients aged [age range] years old.
• Angiosarcoma is more commonly observed among [elderly patients/young patients/children].

Gender

• Angiosarcoma affects men and women equally.

• [Gender 1] are more commonly affected with angiosarcoma than [gender 2].
• The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.

Race

• There is no racial predilection for angiosarcoma.

• Angiosarcoma usually affects individuals of the [race 1] race.
• [Race 2] individuals are less likely to develop angiosarcoma.

Risk Factors

• Common risk factors in the development of angiosarcoma are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

• The majority of patients with angiosarcoma remain asymptomatic for [duration/years].
• Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
• If left untreated, [#%] of patients with angiosarcoma may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
• Common complications of angiosarcoma include [complication 1], [complication 2], and [complication 3].
• Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with angiosarcoma is approximately [#%].

Diagnosis

Diagnostic Criteria

• The diagnosis of angiosarcoma is made when at least [number] of the following [number] diagnostic criteria are met:

• [criterion 1]
• [criterion 2]
• [criterion 3]
• [criterion 4]

Symptoms

• Angiosarcoma is usually asymptomatic.
• Symptoms of angiosarcoma may include the following:

• [symptom 1]
• [symptom 2]
• [symptom 3]
• [symptom 4]
• [symptom 5]
• [symptom 6]

Physical Examination

• Patients with angiosarcoma usually appear [general appearance].
• Physical examination may be remarkable for:

• [finding 1]
• [finding 2]
• [finding 3]
• [finding 4]
• [finding 5]
• [finding 6]

Laboratory Findings

• There are no specific laboratory findings associated with angiosarcoma.

• A [positive/negative] [test name] is diagnostic of angiosarcoma.
• An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of angiosarcoma.
• Other laboratory findings consistent with the diagnosis of angiosarcoma include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

• There are no [imaging study] findings associated with angiosarcoma.

• [Imaging study 1] is the imaging modality of choice for angiosarcoma.
• On [imaging study 1], angiosarcoma is characterized by [finding 1], [finding 2], and [finding 3].
• [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

• Angiosarcoma may also be diagnosed using [diagnostic study name].
• Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

• There is no treatment for angiosarcoma; the mainstay of therapy is supportive care.

• The mainstay of therapy for angiosarcoma is [medical therapy 1] and [medical therapy 2].
• [Medical therapy 1] acts by [mechanism of action1].
• Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

• Surgery is the mainstay of therapy for angiosarcoma.
• [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of angiosarcoma.
• [Surgical procedure] can only be performed for patients with [disease stage] angiosarcoma.

Prevention

• There are no primary preventive measures available for angiosarcoma.

• Effective measures for the primary prevention of angiosarcoma include [measure1], [measure2], and [measure3].

• Once diagnosed and successfully treated, patients with angiosarcoma are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].