Cholangitis laboratory findings: Difference between revisions
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*Elevated serum [[alkaline phosphatase]]<ref name="pmid22086533">{{cite journal |vauthors=Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA |title=The best approach for diagnosing primary sclerosing cholangitis |journal=Clinics (Sao Paulo) |volume=66 |issue=11 |pages=1987–9 |year=2011 |pmid=22086533 |pmc=3203975 |doi= |url=}}</ref> | *Elevated serum [[alkaline phosphatase]]<ref name="pmid22086533">{{cite journal |vauthors=Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA |title=The best approach for diagnosing primary sclerosing cholangitis |journal=Clinics (Sao Paulo) |volume=66 |issue=11 |pages=1987–9 |year=2011 |pmid=22086533 |pmc=3203975 |doi= |url=}}</ref> | ||
*Elevated | *Elevated gammaglutamyl transpeptidase (GGT)<ref name="pmid22086533">{{cite journal |vauthors=Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA |title=The best approach for diagnosing primary sclerosing cholangitis |journal=Clinics (Sao Paulo) |volume=66 |issue=11 |pages=1987–9 |year=2011 |pmid=22086533 |pmc=3203975 |doi= |url=}}</ref> | ||
*Elevated conjugated (direct) [[bilirubin]]<ref name="pmid22086533">{{cite journal |vauthors=Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA |title=The best approach for diagnosing primary sclerosing cholangitis |journal=Clinics (Sao Paulo) |volume=66 |issue=11 |pages=1987–9 |year=2011 |pmid=22086533 |pmc=3203975 |doi= |url=}}</ref> | *Elevated conjugated (direct) [[bilirubin]]<ref name="pmid22086533">{{cite journal |vauthors=Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA |title=The best approach for diagnosing primary sclerosing cholangitis |journal=Clinics (Sao Paulo) |volume=66 |issue=11 |pages=1987–9 |year=2011 |pmid=22086533 |pmc=3203975 |doi= |url=}}</ref> | ||
*Elevated serum [[amylase]] | *Elevated serum [[amylase]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farwa Haideri [2]
Overview
Laboratory tests provide useful clues in the diagnosis of cholangitis. Some commonly conducted tests are complete blood count, basic metabolic panel, liver function tests, blood culture, and other body fluid culture.
Laboratory Findings
Complete Blood Count
- Neutrophilic leucocytosis[1]
Cholestatic Pattern of Liver Function Tests
- Blood culture[1]
- Elevated serum alkaline phosphatase[2]
- Elevated gammaglutamyl transpeptidase (GGT)[2]
- Elevated conjugated (direct) bilirubin[2]
- Elevated serum amylase
- Levels may be as high as 3-4 times of normal, representing pancreatitis.[1]
- Culture from bile obtained during ERCP (endoscopic retrograde cholangiopancreatography)[3]
- Elevated aminotransferases (as high as 1000 IU/L) reflecting hepatocytes injury and microabscess formation.[1]
- Liver abscess is indicated in such cases.
References
- ↑ 1.0 1.1 1.2 1.3 Liu, Chi-Leung. & Fan, Sheung-Tat. (2001), Surgical Treatment: Evidence-Based and Problem-Oriented., Munich, Germany: Zuckschwerdt Verlag
- ↑ 2.0 2.1 2.2 Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA (2011). "The best approach for diagnosing primary sclerosing cholangitis". Clinics (Sao Paulo). 66 (11): 1987–9. PMC 3203975. PMID 22086533.
- ↑ Björnsson ES, Kilander AF, Olsson RG (2000). "Bile duct bacterial isolates in primary sclerosing cholangitis and certain other forms of cholestasis--a study of bile cultures from ERCP". Hepatogastroenterology. 47 (36): 1504–8. PMID 11148988.