Osteomyelitis laboratory findings: Difference between revisions

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Revision as of 19:28, 2 May 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nate Michalak, B.A.

Microbiology and histopathology are essential for diagnosis and determining treatment of osteomyelitis.

Histopathology of bone biopsy samples typically provides the most accurate diagnosis.
Blood cultures are typically more reliable for hematogenous or vertebral ostermyelitis.
Samples obtained from swabbing sinus tracts should not be used as the isolate may be contaminated with non-pathogenic microorganisms.

Isolation techniques to determine causative agent include:

Laboratory tests to determine infection include:

Complete blood count (CBC)
C-reactive protein (CRP)
Erythrocyte sedimentation rate (ESR)
Note: white blood cell count (WBC) is typically normal and therefore not reliable

@@ Line 6: / Line 6: @@
 ==Laboratory Findings==
-Diagnosis of osteomyelitis is often based on [[radiology|radiologic]] results showing a [[lytic]] center with a ring of [[sclerosis]], though bone cultures are normally required to identify the specific pathogen.
+Microbiology and histopathology are essential for diagnosis and determining treatment of osteomyelitis.
+*Histopathology of bone biopsy samples typically provides the most accurate diagnosis.
+*Blood cultures are typically more reliable for hematogenous or vertebral ostermyelitis.
+*Samples obtained from swabbing sinus tracts should not be used as the isolate may be contaminated with non-pathogenic microorganisms.
+Isolation techniques to determine causative agent include:
 *[[Blood culture]]s
 *Bone [[biopsy]] (which is then cultured)
+Laboratory tests to determine infection include:
 *[[Complete blood count]] (CBC)
 *[[C-reactive protein]] (CRP)
 *[[Erythrocyte sedimentation rate]] (ESR)
-*Needle aspiration of the area around affected bones
+*Note: white blood cell count (WBC) is typically normal and therefore not reliable
 ==References==