Primary lymphoma of the bone

WikiDoc Resources for Primary lymphoma of the bone
Articles
Most recent articles on Primary lymphoma of the bone Most cited articles on Primary lymphoma of the bone Review articles on Primary lymphoma of the bone Articles on Primary lymphoma of the bone in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Primary lymphoma of the bone Images of Primary lymphoma of the bone Photos of Primary lymphoma of the bone Podcasts & MP3s on Primary lymphoma of the bone Videos on Primary lymphoma of the bone
Evidence Based Medicine
Cochrane Collaboration on Primary lymphoma of the bone Bandolier on Primary lymphoma of the bone TRIP on Primary lymphoma of the bone
Clinical Trials
Ongoing Trials on Primary lymphoma of the bone at Clinical Trials.gov Trial results on Primary lymphoma of the bone Clinical Trials on Primary lymphoma of the bone at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Primary lymphoma of the bone NICE Guidance on Primary lymphoma of the bone NHS PRODIGY Guidance FDA on Primary lymphoma of the bone CDC on Primary lymphoma of the bone
Books
Books on Primary lymphoma of the bone
News
Primary lymphoma of the bone in the news Be alerted to news on Primary lymphoma of the bone News trends on Primary lymphoma of the bone
Commentary
Blogs on Primary lymphoma of the bone
Definitions
Definitions of Primary lymphoma of the bone
Patient Resources / Community
Patient resources on Primary lymphoma of the bone Discussion groups on Primary lymphoma of the bone Patient Handouts on Primary lymphoma of the bone Directions to Hospitals Treating Primary lymphoma of the bone Risk calculators and risk factors for Primary lymphoma of the bone
Healthcare Provider Resources
Symptoms of Primary lymphoma of the bone Causes & Risk Factors for Primary lymphoma of the bone Diagnostic studies for Primary lymphoma of the bone Treatment of Primary lymphoma of the bone
Continuing Medical Education (CME)
CME Programs on Primary lymphoma of the bone
International
Primary lymphoma of the bone en Espanol Primary lymphoma of the bone en Francais
Business
Primary lymphoma of the bone in the Marketplace Patents on Primary lymphoma of the bone
Experimental / Informatics
List of terms related to Primary lymphoma of the bone

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3

Historical Perspective

• Primary lymphoma of the bone was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
• In [year], [gene] mutations were first identified in the pathogenesis of primary lymphoma of the bone.
• In [year], the first [discovery] was developed by [scientist] to treat/diagnose primary lymphoma of the bone.

Classification

• Primary lymphoma of the bone may be classified according to [classification method] into [number] subtypes/groups:

• [group1]
• [group2]
• [group3]

• Other variants of primary lymphoma of the bone include [disease subtype 1], [disease subtype 2], and [disease subtype 3].

Pathophysiology

• The pathogenesis of primary lymphoma of the bone is characterized by [feature1], [feature2], and [feature3].
• The [gene name] gene/Mutation in [gene name] has been associated with the development of primary lymphoma of the bone, involving the [molecular pathway] pathway.
• On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of primary lymphoma of the bone.
• On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of primary lymphoma of the bone.

Causes

• Primary lymphoma of the bone may be caused by either [cause1], [cause2], or [cause3].
• Primary lymphoma of the bone is caused by a mutation in the [gene1], [gene2], or [gene3] gene[s].
• There are no established causes for primary lymphoma of the bone.

Differentiating primary lymphoma of the bone from other Diseases

• Primary lymphoma of the bone must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:

• [Differential dx1]
• [Differential dx2]
• [Differential dx3]

Epidemiology and Demographics

• The prevalence of primary lymphoma of the bone is approximately [number or range] per 100,000 individuals worldwide.
• In [year], the incidence of primary lymphoma of the bone was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

• Patients of all age groups may develop primary lymphoma of the bone.

• Primary lymphoma of the bone is more commonly observed among patients aged [age range] years old.
• Primary lymphoma of the bone is more commonly observed among [elderly patients/young patients/children].

Gender

• Primary lymphoma of the bone affects men and women equally.

• [Gender 1] are more commonly affected with primary lymphoma of the bone than [gender 2].
• The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.

Race

• There is no racial predilection for primary lymphoma of the bone.

• Primary lymphoma of the bone usually affects individuals of the [race 1] race.
• [Race 2] individuals are less likely to develop primary lymphoma of the bone.

Risk Factors

• Common risk factors in the development of primary lymphoma of the bone are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

Natural History, Complications and Prognosis

• The majority of patients with primary lymphoma of the bone remain asymptomatic for [duration/years].
• Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
• If left untreated, [#%] of patients with primary lymphoma of the bone may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
• Common complications of primary lymphoma of the bone include [complication 1], [complication 2], and [complication 3].
• Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with primary lymphoma of the bone is approximately [#%].

Diagnosis

Diagnostic Criteria

• The diagnosis of primary lymphoma of the bone is made when at least [number] of the following [number] diagnostic criteria are met:

• [criterion 1]
• [criterion 2]
• [criterion 3]
• [criterion 4]

Symptoms

• Primary lymphoma of the bone is usually asymptomatic.
• Symptoms of primary lymphoma of the bone may include the following:

• [symptom 1]
• [symptom 2]
• [symptom 3]
• [symptom 4]
• [symptom 5]
• [symptom 6]

Physical Examination

• Patients with primary lymphoma of the bone usually appear [general appearance].
• Physical examination may be remarkable for:

• [finding 1]
• [finding 2]
• [finding 3]
• [finding 4]
• [finding 5]
• [finding 6]

Laboratory Findings

• There are no specific laboratory findings associated with primary lymphoma of the bone.

• A [positive/negative] [test name] is diagnostic of primary lymphoma of the bone.
• An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of primary lymphoma of the bone.
• Other laboratory findings consistent with the diagnosis of primary lymphoma of the bone include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

• There are no [imaging study] findings associated with primary lymphoma of the bone.

• [Imaging study 1] is the imaging modality of choice for primary lymphoma of the bone.
• On [imaging study 1], primary lymphoma of the bone is characterized by [finding 1], [finding 2], and [finding 3].
• [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

• Primary lymphoma of the bone may also be diagnosed using [diagnostic study name].
• Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

• There is no treatment for primary lymphoma of the bone; the mainstay of therapy is supportive care.

• The mainstay of therapy for primary lymphoma of the bone is [medical therapy 1] and [medical therapy 2].
• [Medical therapy 1] acts by [mechanism of action1].
• Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].

Surgery

• Surgery is the mainstay of therapy for primary lymphoma of the bone.
• [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of primary lymphoma of the bone.
• [Surgical procedure] can only be performed for patients with [disease stage] primary lymphoma of the bone.

Prevention

• There are no primary preventive measures available for primary lymphoma of the bone.

• Effective measures for the primary prevention of primary lymphoma of the bone include [measure1], [measure2], and [measure3].

• Once diagnosed and successfully treated, patients with primary lymphoma of the bone are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].