Bronchiolitis laboratory tests: Difference between revisions
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Evidence has not shown benefit in the use of laboratory tests for the diagnosis of bronchiolitis or for the assessment of severity. Diagnosis of bronchiolitis and of the severe forms of the disease should be made based on clinical findings and risk factors. | Evidence has not shown benefit in the use of laboratory tests for the diagnosis of bronchiolitis or for the assessment of severity. Diagnosis of bronchiolitis and of the severe forms of the disease should be made based on clinical findings and risk factors. | ||
Specific viral testing has not shown benefits as there won't be any changes in the management nor the prognosis of the disease if the specific pathogen is determined. However, some institutions use specific RSV tests to prevent nosocomial spread of the disease.<ref name="pmid14757603">{{cite journal| author=Bordley WC, Viswanathan M, King VJ, Sutton SF, Jackman AM, Sterling L et al.| title=Diagnosis and testing in bronchiolitis: a systematic review. | journal=Arch Pediatr Adolesc Med | year= 2004 | volume= 158 | issue= 2 | pages= 119-26 | pmid=14757603 | doi=10.1001/archpedi.158.2.119 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14757603 }} </ref> | *Specific viral testing has not shown benefits as there won't be any changes in the management nor the prognosis of the disease if the specific pathogen is determined. However, some institutions use specific RSV tests to prevent nosocomial spread of the disease.<ref name="pmid14757603">{{cite journal| author=Bordley WC, Viswanathan M, King VJ, Sutton SF, Jackman AM, Sterling L et al.| title=Diagnosis and testing in bronchiolitis: a systematic review. | journal=Arch Pediatr Adolesc Med | year= 2004 | volume= 158 | issue= 2 | pages= 119-26 | pmid=14757603 | doi=10.1001/archpedi.158.2.119 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14757603 }} </ref> | ||
Specific viral pathogen tests are available. Specific antigen based tests are more commonly used:<ref name="Mendell">{{Cite book | last1 = Mandell | first1 = Gerald L. | last2 = Bennett | first2 = John E. (John Eugene) | last3 = Dolin | first3 = Raphael. | title = Mandell, Douglas, and Bennett's principles and practice of infectious disease | date = 2010 | publisher = Churchill Livingstone/Elsevier | location = Philadelphia, PA | isbn = | pages = }}</ref> | Specific viral pathogen tests are available. Specific antigen based tests are more commonly used:<ref name="Mendell">{{Cite book | last1 = Mandell | first1 = Gerald L. | last2 = Bennett | first2 = John E. (John Eugene) | last3 = Dolin | first3 = Raphael. | title = Mandell, Douglas, and Bennett's principles and practice of infectious disease | date = 2010 | publisher = Churchill Livingstone/Elsevier | location = Philadelphia, PA | isbn = | pages = }}</ref> | ||
*[[ELISA]] | *[[ELISA]] | ||
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*[[Human metapneumovirus]] | *[[Human metapneumovirus]] | ||
The [[complete blood counts]] (CBC) vary in each child and have not shown benefits for the diagnosis of bronchiolitis.<ref name="Mendell">{{Cite book | last1 = Mandell | first1 = Gerald L. | last2 = Bennett | first2 = John E. (John Eugene) | last3 = Dolin | first3 = Raphael. | title = Mandell, Douglas, and Bennett's principles and practice of infectious disease | date = 2010 | publisher = Churchill Livingstone/Elsevier | location = Philadelphia, PA | isbn = | pages = }}</ref> | *The [[complete blood counts]] (CBC) vary in each child and have not shown benefits for the diagnosis of bronchiolitis.<ref name="Mendell">{{Cite book | last1 = Mandell | first1 = Gerald L. | last2 = Bennett | first2 = John E. (John Eugene) | last3 = Dolin | first3 = Raphael. | title = Mandell, Douglas, and Bennett's principles and practice of infectious disease | date = 2010 | publisher = Churchill Livingstone/Elsevier | location = Philadelphia, PA | isbn = | pages = }}</ref> | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alonso Alvarado, M.D. [2]
Overview
Laboratory Findings
Evidence has not shown benefit in the use of laboratory tests for the diagnosis of bronchiolitis or for the assessment of severity. Diagnosis of bronchiolitis and of the severe forms of the disease should be made based on clinical findings and risk factors.
- Specific viral testing has not shown benefits as there won't be any changes in the management nor the prognosis of the disease if the specific pathogen is determined. However, some institutions use specific RSV tests to prevent nosocomial spread of the disease.[1]
Specific viral pathogen tests are available. Specific antigen based tests are more commonly used:[2]
- ELISA
- Direct immunofluorescent assays
- Indirect immunofluorescent assays
- Optical immunoassays
Tests are available for the following viruses:
- The complete blood counts (CBC) vary in each child and have not shown benefits for the diagnosis of bronchiolitis.[2]
References
- ↑ Bordley WC, Viswanathan M, King VJ, Sutton SF, Jackman AM, Sterling L; et al. (2004). "Diagnosis and testing in bronchiolitis: a systematic review". Arch Pediatr Adolesc Med. 158 (2): 119–26. doi:10.1001/archpedi.158.2.119. PMID 14757603.
- ↑ 2.0 2.1 Mandell, Gerald L.; Bennett, John E. (John Eugene); Dolin, Raphael. (2010). Mandell, Douglas, and Bennett's principles and practice of infectious disease. Philadelphia, PA: Churchill Livingstone/Elsevier.