Cushing's disease: Difference between revisions
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==[[Cushing’s disease overview|Overview]]== | ==[[Cushing’s disease overview|Overview]]== | ||
'''Cushing's disease''' (also known as '''Cushing disease''', '''tertiary or secondary hypercortisolism''', '''tertiary or secondary hypercorticism''', '''Itsenko-Cushing disease''')<ref>[http://www.whonamedit.com/doctor.cfm/1520.html "Whonamedit - Nikolai Mikhailovich Itsenko"]. "Nikolai Mikhailovich Itsenko investigated neural infections, vegetative nervous system diseases and cerebral tumors. In 1926 he was the first one who described Itsenko-Cushing's disease, six years before Cushing."</ref><ref name="gozhenko">{{cite book|author=A.I. Gozhenko, I.P. Gurkalova, W. Zukow, Z. Kwasnik, B. Mroczkowska |title =Pathology: Medical Student's Library|chapter =Trematoda|publisher =Radomska Szkola Wyžsza uk. Zubrzyckiego|year =2009|page=280|isbn =978-83-61047-18-6|url =http://books.google.com.ph/books?id=Pvk0MoLNjgYC&lpg=PA280&dq=Itsenko-Cushing's%20disease%20and%20Itsenko-Cushing's%20syndrome%5C&pg=PA280#v=onepage&q=Itsenko-Cushing's%20disease%20and%20Itsenko-Cushing's%20syndrome%5C&f=false}}</ref> is a cause of [[Cushing's syndrome]] characterised by increased secretion of [[adrenocorticotropic hormone]] (ACTH) from the [[anterior pituitary]] ('''secondary''' [[hypercortisolism]]). This is most often as a result of a pituitary [[adenoma]] (specifically pituitary basophilism) or due to excess production of hypothalamus CRH ([[Corticotropin releasing hormone]]) ('''tertiary''' hypercortisolism/hypercorticism) that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome,<ref name="cushing's" /> when excluding Cushing's syndrome from exogenously administered [[corticosteroid]]s. | |||
This should not be confused with [[Cushing's syndrome#Pathophysiology|ectopic Cushing syndrome]] or exogenous steroid use.<ref>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001443/</ref> | |||
==[[Cushing’s disease historical perspective|Historical Perspective]]== | ==[[Cushing’s disease historical perspective|Historical Perspective]]== | ||
Revision as of 14:54, 2 June 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Cushing's disease (also known as Cushing disease, tertiary or secondary hypercortisolism, tertiary or secondary hypercorticism, Itsenko-Cushing disease)[1][2] is a cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism). This is most often as a result of a pituitary adenoma (specifically pituitary basophilism) or due to excess production of hypothalamus CRH (Corticotropin releasing hormone) (tertiary hypercortisolism/hypercorticism) that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome,[3] when excluding Cushing's syndrome from exogenously administered corticosteroids.
This should not be confused with ectopic Cushing syndrome or exogenous steroid use.[4]
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Any Disease from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram |Chest X Ray | CT | MRI | | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
- ↑ "Whonamedit - Nikolai Mikhailovich Itsenko". "Nikolai Mikhailovich Itsenko investigated neural infections, vegetative nervous system diseases and cerebral tumors. In 1926 he was the first one who described Itsenko-Cushing's disease, six years before Cushing."
- ↑ A.I. Gozhenko, I.P. Gurkalova, W. Zukow, Z. Kwasnik, B. Mroczkowska (2009). "Trematoda". Pathology: Medical Student's Library. Radomska Szkola Wyžsza uk. Zubrzyckiego. p. 280. ISBN 978-83-61047-18-6.
- ↑ Invalid
<ref>tag; no text was provided for refs namedcushing's - ↑ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001443/