Glanzmann's thrombasthenia physical examination: Difference between revisions

	Glanzmann's thrombasthenia
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Revision as of 06:13, 20 July 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Patients with Glanzmann’s thrombasthenia may be asymptomatic, or they could manifest mucosal bleeding, ecchymoses,petechiae and purpura or current bleeding on physical exam.^[1]

Physical examination

Appearance of the Patient

Patient appears well in the the absence of severe hemorrhage
Patient appears ill in the persistent bleeding .

Vital Signs

may haveTachycardia, depends on the severity of the bleeding.
may haveTachypnea depends on severity of the bleeding

Skin

Cyanosis
Pallor
- Secondary to anemia
Ecchymoses,petechiae and purpura
- Secondary to thrombocytopenia

HEENT

Abnormalities of the head may include
Evidence of trauma
pale conjunctiva
Epistaxis
palatal petechiae,
gingival or other oral bleeding.

Neck

No specific sign.

Lungs

commonly normal lung sounds.

Heart

commonly normal heart sounds

Abdomen

The spleen is usually non palpable.

Neuromuscular

Patient is usually oriented to persons, place, and time
Glasgow coma scale is normally 15 / 15 but may may present loss of consciousness in severe fatal hemorrhage episodes. ^[2]

Gallery

Extremities

Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[3]

Glanzmann’s trombastenia. With permission from Dermatology Atlas.^[3]

References

↑ Nurden AT, Pillois X, Wilcox DA (2013). "Glanzmann thrombasthenia: state of the art and future directions". Semin Thromb Hemost. 39 (6): 642–55. doi:10.1055/s-0033-1353393. PMC 4011384. PMID 23929305.
↑ Nurden AT (2006). "Glanzmann thrombasthenia". Orphanet J Rare Dis. 1: 10. doi:10.1186/1750-1172-1-10. PMC 1475837. PMID 16722529.
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 "Dermatology Atlas".

[pmid23929305-1] Nurden AT, Pillois X, Wilcox DA (2013). "Glanzmann thrombasthenia: state of the art and future directions". Semin Thromb Hemost. 39 (6): 642–55. doi:10.1055/s-0033-1353393. PMC 4011384. PMID 23929305.

[pmid16722529-2] Nurden AT (2006). "Glanzmann thrombasthenia". Orphanet J Rare Dis. 1: 10. doi:10.1186/1750-1172-1-10. PMC 1475837. PMID 16722529.

[www.atlasdermatologico.com.br-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 "Dermatology Atlas".

[1]

[2]

[3]

@@ Line 5: / Line 5: @@
 ==Overview==
+Patients with Glanzmann’s thrombasthenia may be asymptomatic, or they could manifest mucosal bleeding, ecchymoses,petechiae and purpura or current bleeding on physical exam.<ref name="pmid23929305">{{cite journal| author=Nurden AT, Pillois X, Wilcox DA| title=Glanzmann thrombasthenia: state of the art and future directions. | journal=Semin Thromb Hemost | year= 2013 | volume= 39 | issue= 6 | pages= 642-55 | pmid=23929305 | doi=10.1055/s-0033-1353393 | pmc=4011384 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23929305  }}</ref>
 ==Physical examination==
+=== Appearance of the Patient ===
+* Patient appears well in the the absence of severe hemorrhage
+* Patient appears ill in the persistent bleeding .
+=== Vital Signs ===
+* may have[[Tachycardia]], depends on the severity of the bleeding.
+* may have[[Tachypnea]] depends on severity of the bleeding
+=== Skin ===
+* [[Cyanosis]]
+* [[Pallor]]
+** Secondary to [[anemia]]
+* [[Ecchymoses]],[[petechiae]] and [[purpura]]
+** Secondary to [[thrombocytopenia]]
+=== HEENT ===
+* Abnormalities of the head may include
+* Evidence of trauma
+* pale conjunctiva
+* [[Epistaxis]]
+* palatal petechiae,
+* gingival or other oral bleeding.
+=== Neck ===
+No specific sign.
+=== Lungs ===
+* commonly normal lung sounds.
+=== Heart ===
+* commonly normal heart sounds
+=== Abdomen ===
+The spleen is usually non palpable.
+=== Neuromuscular ===
+* Patient is usually oriented to persons, place, and time
+* Glasgow coma scale is normally 15 / 15 but may may present loss of consciousness in severe fatal hemorrhage episodes. <ref name="pmid16722529">{{cite journal| author=Nurden AT| title=Glanzmann thrombasthenia. | journal=Orphanet J Rare Dis | year= 2006 | volume= 1 | issue=  | pages= 10 | pmid=16722529 | doi=10.1186/1750-1172-1-10 | pmc=1475837 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16722529  }}</ref>
 ===Gallery===