Thrombophilia screening: Difference between revisions
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==Overview== | ==Overview== | ||
==Screening== | ==Screening== | ||
* The American Society of Hematology recommends against thrombophilia screening in adult patients with venous [[thrombosis]] in the setting of major transient risk factors<ref name="pmid24319155">{{cite journal| author=Hicks LK, Bering H, Carson KR, Kleinerman J, Kukreti V, Ma A et al.| title=The ASH Choosing Wisely®campaign: five hematologic tests and treatments to question. | journal=Hematology Am Soc Hematol Educ Program | year= 2013 | volume= 2013 | issue= | pages= 9-14 | pmid=24319155 | doi=10.1182/asheducation-2013.1.9 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24319155 }} </ref>. | * The American Society of Hematology recommends against thrombophilia screening in adult patients with venous [[thrombosis]] in the setting of major transient risk factors which include surgery, trauma, or prolonged immobility<ref name="pmid24319155">{{cite journal| author=Hicks LK, Bering H, Carson KR, Kleinerman J, Kukreti V, Ma A et al.| title=The ASH Choosing Wisely®campaign: five hematologic tests and treatments to question. | journal=Hematology Am Soc Hematol Educ Program | year= 2013 | volume= 2013 | issue= | pages= 9-14 | pmid=24319155 | doi=10.1182/asheducation-2013.1.9 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24319155 }} </ref>. | ||
* | * However, given the [[Thrombophilia_natural_history,_complications_and_prognosis|associated risks]] for recurrent thrombosis, patients who have significant risk factors including a positive family history or concurrent treatment with hormonal therapies should seek expert consultation. | ||
* Therefore, screening may be useful in the following situations<ref name="pmid21340752">{{cite journal| author=Middeldorp S| title=Evidence-based approach to thrombophilia testing. | journal=J Thromb Thrombolysis | year= 2011 | volume= 31 | issue= 3 | pages= 275-81 | pmid=21340752 | doi=10.1007/s11239-011-0572-y | pmc=3056012 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21340752 }} </ref>: | |||
* | ** Family history of homozygosity for factor V leiden, antithrombin deficiency, protein C or S deficiency. | ||
** Patients who may use oral contraceptive pills or become pregnany, might benefit from screening. | |||
*Screening can be expensive, and are often performed at inappropriate times. | |||
* Refer to [[Thrombophilia_laboratory_findings|thrombophilia laboratory findings]] for more information on specific screening tests. | * Refer to [[Thrombophilia_laboratory_findings|thrombophilia laboratory findings]] for more information on specific screening tests. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Asiri Ediriwickrema, M.D., M.H.S. [2]
Overview
Screening
- The American Society of Hematology recommends against thrombophilia screening in adult patients with venous thrombosis in the setting of major transient risk factors which include surgery, trauma, or prolonged immobility[1].
- However, given the associated risks for recurrent thrombosis, patients who have significant risk factors including a positive family history or concurrent treatment with hormonal therapies should seek expert consultation.
- Therefore, screening may be useful in the following situations[2]:
- Family history of homozygosity for factor V leiden, antithrombin deficiency, protein C or S deficiency.
- Patients who may use oral contraceptive pills or become pregnany, might benefit from screening.
- Screening can be expensive, and are often performed at inappropriate times.
- Refer to thrombophilia laboratory findings for more information on specific screening tests.
References
- ↑ Hicks LK, Bering H, Carson KR, Kleinerman J, Kukreti V, Ma A; et al. (2013). "The ASH Choosing Wisely®campaign: five hematologic tests and treatments to question". Hematology Am Soc Hematol Educ Program. 2013: 9–14. doi:10.1182/asheducation-2013.1.9. PMID 24319155.
- ↑ Middeldorp S (2011). "Evidence-based approach to thrombophilia testing". J Thromb Thrombolysis. 31 (3): 275–81. doi:10.1007/s11239-011-0572-y. PMC 3056012. PMID 21340752.