Henoch-Schönlein purpura overview: Difference between revisions
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== Overview == | == Overview == | ||
In [[medicine]] ([[rheumatology]] and [[pediatrics]]) '''Henoch-Schönlein purpura''' (HSP, also known as ''allergic purpura'') is a systemic [[vasculitis]] (inflammation of blood vessels) characterized by deposition of [[immune complex]]es containing the antibody [[IgA]], especially in the skin and kidney. It occurs mainly in children. Typical symptoms include palpable [[purpura]] (small hemorrhages in the skin), [[arthralgia|joint pains]] and [[abdominal pain]]. Most cases are self-limiting and require no treatment apart from symptom control, but the disease may relapse (in 33% of cases) and cause irreversible kidney damage (in 1%).<ref name=Saulsbury2001>{{cite journal |author=Saulsbury FT |title=Henoch-Schönlein purpura |journal=Curr Opin Rheumatol |volume=13|issue=1 |pages=35–40 |year=2001 |pmid=11148713 |doi=}}</ref> | In [[medicine]] ([[rheumatology]] and [[pediatrics]]) '''Henoch-Schönlein purpura''' (HSP, also known as ''allergic purpura'') is a systemic [[vasculitis]] (inflammation of blood vessels) characterized by deposition of [[immune complex]]es containing the antibody [[IgA]], especially in the skin and kidney. It occurs mainly in children. Typical symptoms include palpable [[purpura]] (small hemorrhages in the skin), [[arthralgia|joint pains]] and [[abdominal pain]]. Most cases are self-limiting and require no treatment apart from symptom control, but the disease may relapse (in 33% of cases) and cause irreversible kidney damage (in 1%).<ref name=Saulsbury2001>{{cite journal |author=Saulsbury FT |title=Henoch-Schönlein purpura |journal=Curr Opin Rheumatol |volume=13|issue=1 |pages=35–40 |year=2001 |pmid=11148713 |doi=}}</ref> | ||
==Historical Perspective== | |||
==Historical Perspective== | |||
==Classification== | |||
==Pathophysiology== | |||
==Causes== | |||
==Differentiating Henoch-Schönlein Purpura from other Diseases== | |||
==Epidemiology and Demographics== | |||
==Risk Factors== | |||
==Screening== | |||
==Natural History, Complications and Prognosis== | |||
==Diagnosis== | |||
===History and Symptoms=== | |||
===Physical Examination=== | |||
===Laboratory Findings=== | |||
===Electrocardiogram=== | |||
===Chest X Ray=== | |||
===CT=== | |||
===MRI=== | |||
===Echocardiography or Ultrasound=== | |||
===Other Imaging Findings=== | |||
===Other Diagnostic Studies=== | |||
==Treatment== | |||
===Surgery=== | |||
===Medical Therapy=== | |||
===Primary Prevention=== | |||
===Secondary Prevention=== | |||
===Cost-Effectiveness of Therapy=== | |||
===Future or Investigational Therapies=== | |||
==References== | ==References== | ||
Revision as of 18:27, 28 June 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In medicine (rheumatology and pediatrics) Henoch-Schönlein purpura (HSP, also known as allergic purpura) is a systemic vasculitis (inflammation of blood vessels) characterized by deposition of immune complexes containing the antibody IgA, especially in the skin and kidney. It occurs mainly in children. Typical symptoms include palpable purpura (small hemorrhages in the skin), joint pains and abdominal pain. Most cases are self-limiting and require no treatment apart from symptom control, but the disease may relapse (in 33% of cases) and cause irreversible kidney damage (in 1%).[1]