Thrombophilia history and symptoms: Difference between revisions
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{{Thrombophilia}} | {{Thrombophilia}} | ||
{{CMG}} {{AE}} {{asiri}} | {{CMG}}; {{AE}} {{asiri}} | ||
==Overview== | ==Overview== | ||
Inherited thrombophilias should be suspected in patients with the following clinical presentations. [[Thrombophilia_laboratory_findings|Thrombophilia screening]] may be beneficial in these scenarios.<ref name= | Inherited thrombophilias should be suspected in patients with the following clinical presentations. [[Thrombophilia_laboratory_findings|Thrombophilia screening]] may be beneficial in these scenarios.<ref name=DeLoughery>DeLoughery TG. Hemostasis and Thrombosis: Springer International Publishing; 2014.</ref><ref name="pmid24421360">{{cite journal| author=Cohoon KP, Heit JA| title=Inherited and secondary thrombophilia. | journal=Circulation | year= 2014 | volume= 129 | issue= 2 | pages= 254-7 | pmid=24421360 | doi=10.1161/CIRCULATIONAHA.113.001943 | pmc=3979345 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24421360 }} </ref><ref name="pmid11309638">{{cite journal| author=Seligsohn U, Lubetsky A| title=Genetic susceptibility to venous thrombosis. | journal=N Engl J Med | year= 2001 | volume= 344 | issue= 16 | pages= 1222-31 | pmid=11309638 | doi=10.1056/NEJM200104193441607 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11309638 }} </ref> | ||
==History and Symptoms== | ==History and Symptoms== | ||
*Family history of thrombosis, especially at an early age (< 45 years) | A positive history of the following is suggestive of inherited thrombophilias: | ||
*Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis) | *Family history of [[thrombosis]], especially at an early age (< 45 years) | ||
*Recurrent thrombosis including [[ | *Unprovoked [[thrombosis]] at an early age (<40-55 for [[venous thrombosis]] and <50-55 for [[arterial thrombosis]]) | ||
*Thrombosis at multiple sites, or unusual locations including in cerebral, hepatic, portal, mesenteric, and renal | *Recurrent thrombosis including [[deep venous thrombosis]], [[pulmonary embolus]], or [[superficial venous thrombosis]] | ||
*Thrombosis in arteries with the | *Thrombosis at multiple sites, or unusual locations including in [[internal cerebral veins|cerebral]], [[hepatic vein|hepatic]], [[portal vein|portal]], [[Mesenteric vein thrombosis|mesenteric]], and [[renal vein]]s | ||
*History of fetal loss | *Thrombosis in arteries with the absence of [[Peripheral_arterial_disease|arterial disease]] | ||
*History of [[miscarriage|fetal loss]] | |||
*History of [[Warfarin_necrosis|warfarin skin necrosis]] | *History of [[Warfarin_necrosis|warfarin skin necrosis]] | ||
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[[Category:Hematology]] | [[Category:Hematology]] | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 14:46, 21 July 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Asiri Ediriwickrema, M.D., M.H.S. [2]
Overview
Inherited thrombophilias should be suspected in patients with the following clinical presentations. Thrombophilia screening may be beneficial in these scenarios.[1][2][3]
History and Symptoms
A positive history of the following is suggestive of inherited thrombophilias:
- Family history of thrombosis, especially at an early age (< 45 years)
- Unprovoked thrombosis at an early age (<40-55 for venous thrombosis and <50-55 for arterial thrombosis)
- Recurrent thrombosis including deep venous thrombosis, pulmonary embolus, or superficial venous thrombosis
- Thrombosis at multiple sites, or unusual locations including in cerebral, hepatic, portal, mesenteric, and renal veins
- Thrombosis in arteries with the absence of arterial disease
- History of fetal loss
- History of warfarin skin necrosis
References
- ↑ DeLoughery TG. Hemostasis and Thrombosis: Springer International Publishing; 2014.
- ↑ Cohoon KP, Heit JA (2014). "Inherited and secondary thrombophilia". Circulation. 129 (2): 254–7. doi:10.1161/CIRCULATIONAHA.113.001943. PMC 3979345. PMID 24421360.
- ↑ Seligsohn U, Lubetsky A (2001). "Genetic susceptibility to venous thrombosis". N Engl J Med. 344 (16): 1222–31. doi:10.1056/NEJM200104193441607. PMID 11309638.