Portal hypertension laboratory findings: Difference between revisions
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{{Portal hypertension}} | {{Portal hypertension}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} | ||
==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*There are no diagnostic laboratory findings exclusively associated with portal hypertension. | |||
*Laboratory findings related with the diagnosis of cirrhosis, as the most common underlying disease for portal hypertension, include indirect serum markers and direct fibrosis markers. | |||
=== Indirect serum markers === | |||
==== Platelet count ==== | |||
* Reduced platelet count is the most frequent test used to diagnose portal hypertension in chronic liver disease.<ref name="pmid23058320">{{cite journal |vauthors=Berzigotti A, Seijo S, Arena U, Abraldes JG, Vizzutti F, García-Pagán JC, Pinzani M, Bosch J |title=Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis |journal=Gastroenterology |volume=144 |issue=1 |pages=102–111.e1 |year=2013 |pmid=23058320 |doi=10.1053/j.gastro.2012.10.001 |url=}}</ref> | |||
* 78% of the patients with cirrhosis have thrombocytopenia.<ref name="pmid19281860">{{cite journal |vauthors=Qamar AA, Grace ND, Groszmann RJ, Garcia-Tsao G, Bosch J, Burroughs AK, Ripoll C, Maurer R, Planas R, Escorsell A, Garcia-Pagan JC, Patch D, Matloff DS, Makuch R, Rendon G |title=Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis |journal=Clin. Gastroenterol. Hepatol. |volume=7 |issue=6 |pages=689–95 |year=2009 |pmid=19281860 |pmc=4545534 |doi=10.1016/j.cgh.2009.02.021 |url=}}</ref> | |||
* The probability of esophageal varices are low when the platelet count is normal.<ref name="pmid26047908">{{cite journal |vauthors=de Franchis R |title=Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension |journal=J. Hepatol. |volume=63 |issue=3 |pages=743–52 |year=2015 |pmid=26047908 |doi=10.1016/j.jhep.2015.05.022 |url=}}</ref> | |||
==== ALT/AST index ==== | |||
==== AST/platelet ratio index ==== | |||
==== Lok ==== | |||
==== FIB-4 ==== | |||
==== Forns ==== | |||
=== Direct fibrosis markers === | |||
==== Fibrotest ==== | |||
==== Fibrometer ==== | |||
==== Hepascore ==== | |||
==== Hyaluronic acid ==== | |||
==== Enhanced liver fibrosis ==== | |||
*An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name]. | |||
*Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication]. | |||
==References== | ==References== | ||
Revision as of 21:00, 2 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Laboratory Findings
- There are no diagnostic laboratory findings exclusively associated with portal hypertension.
- Laboratory findings related with the diagnosis of cirrhosis, as the most common underlying disease for portal hypertension, include indirect serum markers and direct fibrosis markers.
Indirect serum markers
Platelet count
- Reduced platelet count is the most frequent test used to diagnose portal hypertension in chronic liver disease.[1]
- 78% of the patients with cirrhosis have thrombocytopenia.[2]
- The probability of esophageal varices are low when the platelet count is normal.[3]
ALT/AST index
AST/platelet ratio index
Lok
FIB-4
Forns
Direct fibrosis markers
Fibrotest
Fibrometer
Hepascore
Hyaluronic acid
Enhanced liver fibrosis
- An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
- Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
References
- ↑ Berzigotti A, Seijo S, Arena U, Abraldes JG, Vizzutti F, García-Pagán JC, Pinzani M, Bosch J (2013). "Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis". Gastroenterology. 144 (1): 102–111.e1. doi:10.1053/j.gastro.2012.10.001. PMID 23058320.
- ↑ Qamar AA, Grace ND, Groszmann RJ, Garcia-Tsao G, Bosch J, Burroughs AK, Ripoll C, Maurer R, Planas R, Escorsell A, Garcia-Pagan JC, Patch D, Matloff DS, Makuch R, Rendon G (2009). "Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis". Clin. Gastroenterol. Hepatol. 7 (6): 689–95. doi:10.1016/j.cgh.2009.02.021. PMC 4545534. PMID 19281860.
- ↑ de Franchis R (2015). "Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension". J. Hepatol. 63 (3): 743–52. doi:10.1016/j.jhep.2015.05.022. PMID 26047908.