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==Epidemiology and Demographics==
==Epidemiology and Demographics==
Post-operative bacetrial endophthalmitis accounts for approximately 60000 cases per 100,000 cases of exogenous endophthalmitis.
*Post-operative bacetrial endophthalmitis accounts for approximately 60000 cases per 100,000 cases of exogenous endophthalmitis.
Endogenous endophthalmitis is a rare disease that tends to affect [[immunocompromised]] patients and patients with [[chronic disease]].
*Endogenous endophthalmitis is a rare disease that tends to affect [[immunocompromised]] patients and patients with [[chronic disease]].
Endogenous endophthalmitis accounts for approximately 5000 to 10000 cases per 100,000 cases with endophthalmitis.<ref name="pmid12850229">{{cite journal| author=Jackson TL, Eykyn SJ, Graham EM, Stanford MR| title=Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases. | journal=Surv Ophthalmol | year= 2003 | volume= 48 | issue= 4 | pages= 403-23 | pmid=12850229 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12850229  }} </ref>
*Endogenous endophthalmitis accounts for approximately 5000 to 10000 cases per 100,000 cases with endophthalmitis.<ref name="pmid12850229">{{cite journal| author=Jackson TL, Eykyn SJ, Graham EM, Stanford MR| title=Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases. | journal=Surv Ophthalmol | year= 2003 | volume= 48 | issue= 4 | pages= 403-23 | pmid=12850229 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12850229  }} </ref>


===Prevalence and Incidence===
===Prevalence and Incidence===
The [[incidence]] of post-traumatic endophthalmitis was estimated to be 4000 to 13000 cases per 100,000 individuals with penetrating ocular injuries.
*The [[incidence]] of post-traumatic endophthalmitis was estimated to be 4000 to 13000 cases per 100,000 individuals with penetrating ocular injuries.
The incidence of endogenous endophthalmitis is about 50 per 100,000 hospitalized patients.<ref name="pmid20390032">{{cite journal| author=Kernt M, Kampik A| title=Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives. | journal=Clin Ophthalmol | year= 2010 | volume= 4 | issue=  | pages= 121-35 | pmid=20390032 | doi= | pmc=2850824 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20390032  }} </ref><ref name="pmid15522366">{{cite journal| author=Essex RW, Yi Q, Charles PG, Allen PJ| title=Post-traumatic endophthalmitis. | journal=Ophthalmology | year= 2004 | volume= 111 | issue= 11 | pages= 2015-22 | pmid=15522366 | doi=10.1016/j.ophtha.2003.09.041 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15522366  }} </ref>  
*The incidence of endogenous endophthalmitis is estimated to be 50 cases per 100,000 hospitalized patients.<ref name="pmid20390032">{{cite journal| author=Kernt M, Kampik A| title=Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives. | journal=Clin Ophthalmol | year= 2010 | volume= 4 | issue=  | pages= 121-35 | pmid=20390032 | doi= | pmc=2850824 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20390032  }} </ref><ref name="pmid15522366">{{cite journal| author=Essex RW, Yi Q, Charles PG, Allen PJ| title=Post-traumatic endophthalmitis. | journal=Ophthalmology | year= 2004 | volume= 111 | issue= 11 | pages= 2015-22 | pmid=15522366 | doi=10.1016/j.ophtha.2003.09.041 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15522366  }} </ref>  
===Age===
===Age===
Post-operative bacterial endophthalmitis (following cataract surgery) commonly affects patients older than 85 years.<ref name="pmid20390032">{{cite journal| author=Kernt M, Kampik A| title=Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives. | journal=Clin Ophthalmol | year= 2010 | volume= 4 | issue=  | pages= 121-35 | pmid=20390032 | doi= | pmc=2850824 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20390032  }} </ref>
*Post-operative bacterial endophthalmitis (following cataract surgery) commonly affects patients older than 85 years.<ref name="pmid20390032">{{cite journal| author=Kernt M, Kampik A| title=Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives. | journal=Clin Ophthalmol | year= 2010 | volume= 4 | issue=  | pages= 121-35 | pmid=20390032 | doi= | pmc=2850824 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20390032  }} </ref>
Patients of all age groups may develop endogenous bacterial endophthalmitis.<ref name="pmid9627649">{{cite journal| author=Aaberg TM, Flynn HW, Schiffman J, Newton J| title=Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes. | journal=Ophthalmology | year= 1998 | volume= 105 | issue= 6 | pages= 1004-10 | pmid=9627649 | doi=10.1016/S0161-6420(98)96000-6 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9627649  }} </ref>
*Patients of all age groups may develop endogenous bacterial endophthalmitis.<ref name="pmid9627649">{{cite journal| author=Aaberg TM, Flynn HW, Schiffman J, Newton J| title=Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes. | journal=Ophthalmology | year= 1998 | volume= 105 | issue= 6 | pages= 1004-10 | pmid=9627649 | doi=10.1016/S0161-6420(98)96000-6 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9627649  }} </ref>
===Gender===
===Gender===
Exogenous and endogenous bacterial endophthalmitis affects men and women equally.<ref name="pmid20390032">{{cite journal| author=Kernt M, Kampik A| title=Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives. | journal=Clin Ophthalmol | year= 2010 | volume= 4 | issue=  | pages= 121-35 | pmid=20390032 | doi= | pmc=2850824 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20390032  }} </ref>
*Exogenous and endogenous bacterial endophthalmitis affects men and women equally.<ref name="pmid20390032">{{cite journal| author=Kernt M, Kampik A| title=Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives. | journal=Clin Ophthalmol | year= 2010 | volume= 4 | issue=  | pages= 121-35 | pmid=20390032 | doi= | pmc=2850824 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20390032  }} </ref>
===Race===
===Race===
In East Asian populations, [[liver abscess]] caused by ''[[Klebsiella pneumoniae]]'' is the source of  60% of cases of endogenous endophthalmitis.<ref name="pmid10919895">{{cite journal| author=Wong JS, Chan TK, Lee HM, Chee SP| title=Endogenous bacterial endophthalmitis: an east Asian experience and a reappraisal of a severe ocular affliction. | journal=Ophthalmology | year= 2000 | volume= 107 | issue= 8 | pages= 1483-91 | pmid=10919895 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10919895  }} </ref>
*In East Asian populations, [[liver abscess]] caused by ''[[Klebsiella pneumoniae]]'' is the source of  60% of cases of endogenous endophthalmitis.<ref name="pmid10919895">{{cite journal| author=Wong JS, Chan TK, Lee HM, Chee SP| title=Endogenous bacterial endophthalmitis: an east Asian experience and a reappraisal of a severe ocular affliction. | journal=Ophthalmology | year= 2000 | volume= 107 | issue= 8 | pages= 1483-91 | pmid=10919895 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10919895  }} </ref>
===Developed countries===
===Developed countries===
In developed countries/United States, post-cataract endophthalmitis is the most common form bacterial endophthalmitis.
*In developed countries/United States, post-cataract endophthalmitis is the most common form bacterial endophthalmitis.
In developed countries/United States, the incidence of post-operative bacterial endophthalmitis was estimated to be 100 to 300 cases per 100,000 individuals who have ophthalmologic operations (mostly [[cataract]]).
*In developed countries/United States, the incidence of post-operative bacterial endophthalmitis was estimated to be 100 to 300 cases per 100,000 individuals who have ophthalmologic operations (mostly [[cataract]]).
.<ref name="pmid9627649">{{cite journal| author=Aaberg TM, Flynn HW, Schiffman J, Newton J| title=Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes. | journal=Ophthalmology | year= 1998 | volume= 105 | issue= 6 | pages= 1004-10 | pmid=9627649 | doi=10.1016/S0161-6420(98)96000-6 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9627649  }} </ref>
.<ref name="pmid9627649">{{cite journal| author=Aaberg TM, Flynn HW, Schiffman J, Newton J| title=Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes. | journal=Ophthalmology | year= 1998 | volume= 105 | issue= 6 | pages= 1004-10 | pmid=9627649 | doi=10.1016/S0161-6420(98)96000-6 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9627649  }} </ref>



Revision as of 19:21, 20 July 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mehrsefat, M.D. [2]

Overview

Bacterial endophthalmitis means bacterial infection inside the eye, involving the vitreous and/or aqueous humors. Most cases of endophthalmitis are exogenous, and organisms are introduced into the eye via trauma, surgery, or an infected cornea. Endogenous endophthalmitis occurs when the eye is seeded via the bloodstream. Patients usually have symptoms from their underlying systemic infection, but sometimes present only with eye symptom.

Historical Perspective

Classification

Based on how infectious agents generally gain access to the posterior segment posterior segment of the eye, bacterial endophthalmitis may be classified into:

  • Exogenous bacterial endophthalmitis
    • Acute post-operative bacterial endophthalmitis
    • Delayed post-operative bacterial endophthalmitis
    • Post-traumatic bacterial endophthalmitis (following a penetrating injury of the globe)
  • Endogenous bacterial endophthalmitis

Pathophysiology

Exogenous bacterial endophthalmitis

Pathogenesis

Acute post-operative bacterial endophthalmitis occurs within 1 week following ocular surgery. It is an ocular inflammation resulting from the introduction of an infectious agent, most commonly coagulase-negative staphylococci, into the posterior segment of the eye. Nearly every type of ocular surgery, such as cataract, glaucoma, retinal, radial keratotomy, and intravitreal injections, may be able to disturb the eye globe integrity and contaminate the aqueous humor. Preoperative topical antimicrobial agents can decrease colony counts in the tear film, but they do not sterilize the area. The exact low rate of clinical infection following eye surgery (despite the relatively high prevalence of microorganisms in the eye) is not fully understood. It is thought that low rate of clinical infection following surgical procedure is explained by combination of low inoculum levels, low pathogenicity, and the innate ocular defenses against infection.

Post-operative bacterial endophthalmitis may also occur weeks to years following surgery. The exact pathogenesis of delayed postoperative bacterial endophthalmitis is not fully understood. It is thought that delayed pos-toperative bacterial endophthalmitis is caused by either sequestration of low-virulence organisms introduced at the time of surgery or delayed inoculation of organisms to the eye through wound abnormalities, suture tracks, or filtering blebs. Propionibacterium acnes is the most common microorganism encountered in delayed post-operative bacterial endophthalmitis.

Post-traumatic bacterial endophthalmitis occurs following penetrating ocular injuries. Following penetrating injury, the eye globe integrity disturbed. Penetrating ocular injuries are accompanied by infection at a much higher rate compere to ocular surgery. The broad prevalence range is due to factors such as:

  • Presence of an intraocular foreign body
  • Delay primary globe repair
  • Location and extent of laceration of the globe

Post-traumatic endophthalmitis associated with a greater variety of organisms. The most common isolated organisms include Gram-positive Staphylococcus epidermidis and Streptococcus (as a part of the normal skin flora and regularly contaminate open wounds). Bacillus cereus is ranked second and some cases are polymicrobial.

Gross Pathology

On gross pathology, eyelid swelling, eyelid erythema, injected conjunctiva and sclera, hypopyon, chemosis, and mucoprulunt dischage are characteristic findings of exogenous bacterial endophthalmitis.

Endogenous bacterial endophthalmitis

Pathogenesis

Endogenous endophthalmitis is typically the result of hematogenous spread from a distant infective source within the body. Endogenous endophthalmitis is commonly associated with immunosuppression or procedures that increase the risk for blood-borne infections, such as diabetes, HIV, malignancy, intravenous drug use, transplantation, immunosuppressive therapy, and catheterization. Under normal circumstances, the blood-ocular barrier provides a natural resistance against invading organisms. Following bacteremia, the blood-borne organisms permeate the blood-ocular barrier by:

Gross Pathology

On gross pathology, findings in endogenous endophthalmitis may be similar to those in infections of exogenous origin.

Microscopic histopathological analysis

On microscopic histopathological analysis, infiltration of polymorphonuclear leukocytes or chronic inflammatory cells (depending on the duration of the inflammation) and destruction of ocular structures are characteristic findings of bacterial endophthalmitis.

Causes

Post-operative Bacterial Endophthalmitis

Post-operative endophthalmitis has been reported following nearly every type of ocular surgery. Common causes of post-operative bacterial endophthalmitis include:

Delayed Post-operative Bacterial Endophthalmitis

Common causes of delayed post-operative bacterial endophthalmitis include:

Post-traumatic Bacterial Endophthalmitis

Common causes of post-traumatic bacterial endophthalmitis include:

Endogenous bacterial endophthalmitis

Common causes of endogenous bacterial endophthalmitis include:

Differentiating Bacterial Endophthalmitis from Other Diseases

Bacterial endophthalmitis must be differentiated from:[1]

Epidemiology and Demographics

  • Post-operative bacetrial endophthalmitis accounts for approximately 60000 cases per 100,000 cases of exogenous endophthalmitis.
  • Endogenous endophthalmitis is a rare disease that tends to affect immunocompromised patients and patients with chronic disease.
  • Endogenous endophthalmitis accounts for approximately 5000 to 10000 cases per 100,000 cases with endophthalmitis.[2]

Prevalence and Incidence

  • The incidence of post-traumatic endophthalmitis was estimated to be 4000 to 13000 cases per 100,000 individuals with penetrating ocular injuries.
  • The incidence of endogenous endophthalmitis is estimated to be 50 cases per 100,000 hospitalized patients.[3][4]

Age

  • Post-operative bacterial endophthalmitis (following cataract surgery) commonly affects patients older than 85 years.[3]
  • Patients of all age groups may develop endogenous bacterial endophthalmitis.[5]

Gender

  • Exogenous and endogenous bacterial endophthalmitis affects men and women equally.[3]

Race

Developed countries

  • In developed countries/United States, post-cataract endophthalmitis is the most common form bacterial endophthalmitis.
  • In developed countries/United States, the incidence of post-operative bacterial endophthalmitis was estimated to be 100 to 300 cases per 100,000 individuals who have ophthalmologic operations (mostly cataract).

.[5]

Risk Factors

Screening

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Imaging Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

References

  1. American Academy of Ophthalmology/eyewiki (2014) http://eyewiki.aao.org/Endophthalmitis Accessed on July 20, 2016
  2. Jackson TL, Eykyn SJ, Graham EM, Stanford MR (2003). "Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases". Surv Ophthalmol. 48 (4): 403–23. PMID 12850229.
  3. 3.0 3.1 3.2 Kernt M, Kampik A (2010). "Endophthalmitis: Pathogenesis, clinical presentation, management, and perspectives". Clin Ophthalmol. 4: 121–35. PMC 2850824. PMID 20390032.
  4. Essex RW, Yi Q, Charles PG, Allen PJ (2004). "Post-traumatic endophthalmitis". Ophthalmology. 111 (11): 2015–22. doi:10.1016/j.ophtha.2003.09.041. PMID 15522366.
  5. 5.0 5.1 Aaberg TM, Flynn HW, Schiffman J, Newton J (1998). "Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes". Ophthalmology. 105 (6): 1004–10. doi:10.1016/S0161-6420(98)96000-6. PMID 9627649.
  6. Wong JS, Chan TK, Lee HM, Chee SP (2000). "Endogenous bacterial endophthalmitis: an east Asian experience and a reappraisal of a severe ocular affliction". Ophthalmology. 107 (8): 1483–91. PMID 10919895.


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