Iron deficiency anemia causes: Difference between revisions

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==Causes <ref name="urlRecommendations to Prevent and Control Iron Deficiency in the United States">{{cite web |url=http://www.cdc.gov/mmwr/preview/mmwrhtml/00051880.htm#top |title=Recommendations to Prevent and Control Iron Deficiency in the United States |format= |work= |accessdate=2012-09-18}}</ref>==
==Causes <ref name="urlRecommendations to Prevent and Control Iron Deficiency in the United States">{{cite web |url=http://www.cdc.gov/mmwr/preview/mmwrhtml/00051880.htm#top |title=Recommendations to Prevent and Control Iron Deficiency in the United States |format= |work= |accessdate=2012-09-18}}</ref>==
===Increased Iron Requirement===
===Life threatening causes===
====Physiological====
* Severe blood loss such as traumatic haemorrhage, haemetemesis, haemoptysis or uncontrolled bleeding from any body part can result in death from hypovolemic shock.
 
===Most common causes===
* [[Growth]]
* [[Growth]]
* [[Pregnancy]]
* [[Pregnancy]]
* Malnutrition
* Malabsorption
* Blood loss
* Chronic Kidney disease
* Anemia of chronic disease
* Myeloproliferative disorders
=== Less common causes ===
* Erythrpoetin/eryhtropoetin stimulating drugs
* Leflunomide
* Pramipexole
* Trientine
=== Genetic cause ===
* IRIDA- iron referactory iron deficiency anemia due to TMPRSS6 mutation
* SLC11A-2 mutation


====Pathological====
====Pathological====
Line 35: Line 53:


===Causes by Organ System===
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
{| style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
|-
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dental'''
| '''Dental'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Chronic gum bleeding
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Leflunomide]], [[Pramipexole]], [[trientine]]
| bgcolor="Beige" | [[Leflunomide]], [[Pramipexole]], [[trientine]], antacids
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Epistaxis
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Erythropoetin deficiency
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Haemetemesis, Celiac disease, bariatric surgery, Gatsritis, esophageal varices, [[Tropical sprue]], [[Whipple's disease]], [[Small intestinal bacterial overgrowth syndrome]], Giardia, Malabsorption
{| class="wikitable"
| colspan="2" |[[Blind loop syndrome]]
|-
| colspan="2" |[[Fistula]]
|-
| colspan="2" |[[Diverticular|Diverticula]]
|-
| colspan="2" |[[Stenosis|Stricture]]
|}
[[Cystic fibrosis]], 
{| class="wikitable"
| colspan="2" |[[Zollinger-Ellison syndrome|Zollinger–Ellison syndrome]]
|-
| colspan="2" |[[VIPoma]]
|-
| colspan="2" |[[Carcinoid syndrome]]
|-
| colspan="2" |[[Bile acid malabsorption]]
|}
{| class="wikitable"
|[[Crohn's disease]]
|-
|-
|-bgcolor="LightSteelBlue"
|[[Ulcerative colitis]]
|}
|-
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | '''''SLC11A2'' mutation, IRIDA'''
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Myeloproliferative disorder
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Erythrpoetin administartion
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | H.pylori, Giardia, Hookworms, Entamoeba histolytica
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Mennorhagia, Fibroids, Post partum bleeding, Pregnancy, Endometriosis
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Colon cancer, esophageal cancer, gastric cancer, pancreatic cancer, lung cancer
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Haemoptysis
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Chronic kidney disease, haemodialysis
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Anemia of chronic disease
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Bleeding
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Haematuria
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | Decreased iron intake, increased body requirements
|-
|-
|}
|}


 
===Causes in alphabetical order===
<div style="-moz-column-count:3; column-count:3;">
* Cause 1
* Cause 2
* Cause 3
* Cause 4
* Cause 5
* Cause 6
* Cause 7
* Cause 8
* Cause 9
* Cause 10
</div>
==External Link==
==External Link==
[http://www.cdc.gov/mmwr/preview/mmwrhtml/00051880.htm Center for disease control and prevention]
[http://www.cdc.gov/mmwr/preview/mmwrhtml/00051880.htm Center for disease control and prevention]

Revision as of 19:59, 14 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Iron deficiency anemia causes can be broadly divided into physiological causes as that seen during growth and pregnancy and due to pathological process. The pathological process could be further divided based on blood loss and inadequate iron absorption.

Causes [1]

Life threatening causes

  • Severe blood loss such as traumatic haemorrhage, haemetemesis, haemoptysis or uncontrolled bleeding from any body part can result in death from hypovolemic shock.

Most common causes

  • Growth
  • Pregnancy
  • Malnutrition
  • Malabsorption
  • Blood loss
  • Chronic Kidney disease
  • Anemia of chronic disease
  • Myeloproliferative disorders

Less common causes

  • Erythrpoetin/eryhtropoetin stimulating drugs
  • Leflunomide
  • Pramipexole
  • Trientine

Genetic cause

  • IRIDA- iron referactory iron deficiency anemia due to TMPRSS6 mutation
  • SLC11A-2 mutation

Pathological

Blood Loss

Inadequate Iron Absorption


Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental Chronic gum bleeding
Dermatologic No underlying causes
Drug Side Effect Leflunomide, Pramipexole, trientine, antacids
Ear Nose Throat Epistaxis
Endocrine Erythropoetin deficiency
Environmental No underlying causes
Gastroenterologic Haemetemesis, Celiac disease, bariatric surgery, Gatsritis, esophageal varices, Tropical sprue, Whipple's disease, Small intestinal bacterial overgrowth syndrome, Giardia, Malabsorption
Blind loop syndrome
Fistula
Diverticula
Stricture

Cystic fibrosis,

Zollinger–Ellison syndrome
VIPoma
Carcinoid syndrome
Bile acid malabsorption
Crohn's disease
Ulcerative colitis
Genetic SLC11A2 mutation, IRIDA
Hematologic Myeloproliferative disorder
Iatrogenic Erythrpoetin administartion
Infectious Disease H.pylori, Giardia, Hookworms, Entamoeba histolytica
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic Mennorhagia, Fibroids, Post partum bleeding, Pregnancy, Endometriosis
Oncologic Colon cancer, esophageal cancer, gastric cancer, pancreatic cancer, lung cancer
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Haemoptysis
Renal/Electrolyte Chronic kidney disease, haemodialysis
Rheumatology/Immunology/Allergy Anemia of chronic disease
Sexual No underlying causes
Trauma Bleeding
Urologic Haematuria
Miscellaneous Decreased iron intake, increased body requirements

Causes in alphabetical order

  • Cause 1
  • Cause 2
  • Cause 3
  • Cause 4
  • Cause 5
  • Cause 6
  • Cause 7
  • Cause 8
  • Cause 9
  • Cause 10

External Link

Center for disease control and prevention

References

  1. ↑ "Recommendations to Prevent and Control Iron Deficiency in the United States". Retrieved 2012-09-18.

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