Hypopituitarism natural history, complications and prognosis: Difference between revisions
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{{Hypopituitarism}} | {{Hypopituitarism}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{AEL}} | ||
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==Overview== | ==Overview== | ||
==Natural History== | ==Natural History== | ||
Hypopituitarism develops different symptoms according to the affected part of the pituitary gland and the deficient hormone. Leaving hypopituitarism without treatment can lead to critical consequences. The natural history depends on the different manifestations of the disease as the following:<ref name="Vance1994">{{cite journal|last1=Vance|first1=Mary Lee|title=Hypopituitarism|journal=New England Journal of Medicine|volume=330|issue=23|year=1994|pages=1651–1662|issn=0028-4793|doi=10.1056/NEJM199406093302306}}</ref> | |||
*'''Hypogonadism''': | |||
**In both genders, if left untreated, it will lead to decrease bone density and osteoporosis.<ref name="KlibanskiNeer1980">{{cite journal|last1=Klibanski|first1=Anne|last2=Neer|first2=Robert M.|last3=Beitins|first3=Inese Z.|last4=Ridgway|first4=E. Chester|last5=Zervas|first5=Nicholas T.|last6=McArthur|first6=Janet W.|title=Decreased Bone Density in Hyperprolactinemic Women|journal=New England Journal of Medicine|volume=303|issue=26|year=1980|pages=1511–1514|issn=0028-4793|doi=10.1056/NEJM198012253032605}}</ref> | |||
**In women, there may be increase risk of coronary artery disease due to depletion of the estrogen level in women.<ref name="MatthewsMeilahn1989">{{cite journal|last1=Matthews|first1=Karen A.|last2=Meilahn|first2=Elaine|last3=Kuller|first3=Lewis H.|last4=Kelsey|first4=Sheryl F.|last5=Caggiula|first5=Arlene W.|last6=Wing|first6=Rena R.|title=Menopause and Risk Factors for Coronary Heart Disease|journal=New England Journal of Medicine|volume=321|issue=10|year=1989|pages=641–646|issn=0028-4793|doi=10.1056/NEJM198909073211004}}</ref> | |||
**In men, decrease muscle mass due to depletion of the testosterone hormone levels. | |||
==Complications== | ==Complications== | ||
Revision as of 14:15, 10 July 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Natural History
Hypopituitarism develops different symptoms according to the affected part of the pituitary gland and the deficient hormone. Leaving hypopituitarism without treatment can lead to critical consequences. The natural history depends on the different manifestations of the disease as the following:[1]
- Hypogonadism:
Complications
Prognosis
Prognosis of hypopituitarism depends on:
- The cause of hypopituitarism: Prognosis of hypopituitarism resulting from tumor is worse than other causes.
- The reaction of hormone replacement therapy.
References
- ↑ Vance, Mary Lee (1994). "Hypopituitarism". New England Journal of Medicine. 330 (23): 1651–1662. doi:10.1056/NEJM199406093302306. ISSN 0028-4793.
- ↑ Klibanski, Anne; Neer, Robert M.; Beitins, Inese Z.; Ridgway, E. Chester; Zervas, Nicholas T.; McArthur, Janet W. (1980). "Decreased Bone Density in Hyperprolactinemic Women". New England Journal of Medicine. 303 (26): 1511–1514. doi:10.1056/NEJM198012253032605. ISSN 0028-4793.
- ↑ Matthews, Karen A.; Meilahn, Elaine; Kuller, Lewis H.; Kelsey, Sheryl F.; Caggiula, Arlene W.; Wing, Rena R. (1989). "Menopause and Risk Factors for Coronary Heart Disease". New England Journal of Medicine. 321 (10): 641–646. doi:10.1056/NEJM198909073211004. ISSN 0028-4793.