Typhoid fever pathophysiology: Difference between revisions
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{{Familytree|boxstyle=width: 300px; text-align: left;background: #FFF0F5| | | | B01 | | | |B01='''Gastrointestinal Infection''' | {{Familytree|boxstyle=width: 300px; text-align: left;background: #FFF0F5| | | | B01 |-| B02| |B01='''Gastrointestinal Infection''' | ||
'''''Stomach''''' | '''''Stomach''''' | ||
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*Internalisation in M cells | *Internalisation in M cells | ||
*Translocation to underlying lymphoid tissue and draining lymph nodes | *Translocation to underlying lymphoid tissue and draining lymph nodes | ||
|B02= '''Systemic spread''' | |||
*Dissemination of ''[[S.typhi]]'' to reticuloendothelial system | *Dissemination of ''[[S.typhi]]'' to reticuloendothelial system | ||
*Spreads via lymph and blood | *Spreads via lymph and blood | ||
*Replication within reticuloendothelial system | *Replication within reticuloendothelial system | ||
*Evades immune system | *Evades immune system | ||
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Revision as of 21:36, 30 August 2016
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Typhoid fever Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Typhoid fever pathophysiology On the Web |
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American Roentgen Ray Society Images of Typhoid fever pathophysiology |
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Risk calculators and risk factors for Typhoid fever pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
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Innoculation
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| Gastrointestinal Infection
Stomach
Small intestine
| Systemic spread
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Chronic carrier state
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Heterozygous advantage
It is thought that cystic fibrosis may have risen to its present levels (1 in 1600 in UK) due to the heterozygous advantage that it confers against typhoid fever. The CFTR protein is present in both the lungs and the intestinal epithelium, and the mutant cystic fibrosis form of the CFTR protein prevents entry of the typhoid bacterium into the body through the intestinal epithelium.