Aphthous ulcer pathophysiology

Aphthous ulcer Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mehrsefat, M.D. [2]

Overview

The pathophysiology of Aphthous ulcers is not fully understood. It is though that reucurren

Pathophysiology

The exact pathogenesis of aphthous ulcer in not clear. Contributing factors include:

• Allergies
• Genetic predisposition
• Hormonal influences
• Hematologic abnormalities
• Immunologic factors
• Infectious agents
• Nutritional deficiencies
• Smoking cessation
• Stress
• Trauma

It is thought that aphthous ulcer is the result of the cross reactivity between Staphylococcus sanguis and 60­kDa Heat shock protein (HSP60)

References

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