Aphthous ulcer pathophysiology: Difference between revisions
No edit summary |
|||
| Line 7: | Line 7: | ||
==Pathophysiology== | ==Pathophysiology== | ||
===Pathogenesis=== | |||
The exact pathogenesis of aphthous ulcer in not clear. | The exact pathogenesis of aphthous ulcer in not clear. | ||
Contributing factors include: | Contributing factors include: | ||
| Line 23: | Line 24: | ||
It is thought aphthous ulcer is a result of is caused by either , [hypothesis 2], or [hypothesis 3]. | It is thought aphthous ulcer is a result of is caused by either , [hypothesis 2], or [hypothesis 3]. | ||
===Associated conditions=== | ===Associated conditions=== | ||
*Systemic disease | |||
**[[Behcet disease]] | |||
**[[MAGIC syndrom|Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome]] | |||
**[[Crohn disease]] | |||
**[[Ulcerative colitis]] | |||
**[[Human immunodeficiency virus infection]] | |||
**Periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) or [[Marshall syndrome]] | |||
**[[Cyclic neutropenia]] | |||
*Microbial | |||
**Bacterial ([[streptococcus|streptococci]]) | |||
**Viral ([[varicella zoster]] and [[cytomegalovirus]]) | |||
*Genetics | |||
**Ethnicity | |||
**[[HLA|Human leukocyte antigen haplotypes]] (HLA B51 | |||
*Allergic/Immunologic | |||
**Local T-lymphocyte cytotoxicity | |||
**Sodium lauryl sulfate sensitivity (in tooth paste) | |||
**Abnormal CD4:CD8 ratio | |||
**Microbe-induced hypersensitivity | |||
**Food sensitivity | |||
*Others | |||
**[[Antioxidants]] | |||
**[[Nonsteroidal anti-inflammatory drugs (NSAIDs)]] | |||
**[[B blockers]] | |||
**[[Immunosuppressive]] drugs | |||
**Stress | |||
**Psychological imbalance | |||
==References== | ==References== | ||
Revision as of 13:13, 6 September 2016
|
Aphthous ulcer Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Aphthous ulcer pathophysiology On the Web |
|
American Roentgen Ray Society Images of Aphthous ulcer pathophysiology |
|
Risk calculators and risk factors for Aphthous ulcer pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mehrsefat, M.D. [2]
Overview
The pathophysiology of Aphthous ulcers is not fully understood. It is though that reucurren
Pathophysiology
Pathogenesis
The exact pathogenesis of aphthous ulcer in not clear. Contributing factors include:
- Allergies
- Genetic predisposition
- Hormonal influences
- Hematologic abnormalities
- Immunologic factors
- Infectious agents
- Nutritional deficiencies
- Smoking cessation
- Stress
- Trauma
It is thought that aphthous ulcer is the result of the cross reactivity between Staphylococcus sanguis and 60kDa Heat shock protein (HSP60)
It is thought aphthous ulcer is a result of is caused by either , [hypothesis 2], or [hypothesis 3].
Associated conditions
- Systemic disease
- Behcet disease
- Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome
- Crohn disease
- Ulcerative colitis
- Human immunodeficiency virus infection
- Periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) or Marshall syndrome
- Cyclic neutropenia
- Microbial
- Bacterial (streptococci)
- Viral (varicella zoster and cytomegalovirus)
- Genetics
- Ethnicity
- Human leukocyte antigen haplotypes (HLA B51
- Allergic/Immunologic
- Local T-lymphocyte cytotoxicity
- Sodium lauryl sulfate sensitivity (in tooth paste)
- Abnormal CD4:CD8 ratio
- Microbe-induced hypersensitivity
- Food sensitivity
- Others
- Antioxidants
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- B blockers
- Immunosuppressive drugs
- Stress
- Psychological imbalance