Chlamydia infection laboratory findings: Difference between revisions

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Revision as of 15:56, 9 September 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Aysha Anwar, M.B.B.S [2]

Overview

Laboratory tests used in the diagnosis of chlamydia infection include nucleic acid amplification tests (NAAT) such as polymerase chain reaction (PCR), transcription mediated amplification (TMA), and the DNA strand displacement assay (SDA). NAAT for chlamydia infection may be performed on swab specimens sampled from the cervix (women) or urethra (men), on self-collected vaginal swabs, or on voided urine.^[1]^[2]^[3]

Laboratory Findings

Laboratory findings consistent with the diagnosis of Chlamydial infection and its complications include:

Type of Chlamydia	Tests	Findings
Neonatal Conjuctivitis	CBC	Normal
Neonatal Conjuctivitis	ESR	Normal
Neonatal pneumonia	CBC	Absolute increase in eosinophil count
	ESR	Increased
	CRP	Increased
Genital infection	CBC	Increased leukocyte count
	Urinalysis	>5 WBCS per high power field
	ESR	Normal or increased
	CRP	Normal or increased
Atypical pneumonia	CBC	Increased absolute eosinophil count
Fitz Hugh Curtis Syndrome	CBC	Increased leukocytes
	LFTS	Normal
	ESR	Normal or increased
	D Dimer	Normal or increased

References

↑ Peipert JF (2003). "Clinical practice. Genital chlamydial infections". N Engl J Med. 349 (25): 2424–30. doi:10.1056/NEJMcp030542. PMID 14681509.
↑ Enwemeka CS, Rodriguez O, Mendosa S (1990). "The biomechanical effects of low-intensity ultrasound on healing tendons". Ultrasound Med Biol. 16 (8): 801–7. PMID 2095010.
↑ Centers for Disease Control and Prevention (2014). "Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae--2014". MMWR Recomm Rep. 63 (RR-02): 1–19. PMC 4047970. PMID 24622331.

Template:WikiDoc Sources

[pmid14681509-1] Peipert JF (2003). "Clinical practice. Genital chlamydial infections". N Engl J Med. 349 (25): 2424–30. doi:10.1056/NEJMcp030542. PMID 14681509.

[pmid2095010-2] Enwemeka CS, Rodriguez O, Mendosa S (1990). "The biomechanical effects of low-intensity ultrasound on healing tendons". Ultrasound Med Biol. 16 (8): 801–7. PMID 2095010.

[pmid24622331-3] Centers for Disease Control and Prevention (2014). "Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae--2014". MMWR Recomm Rep. 63 (RR-02): 1–19. PMC 4047970. PMID 24622331.

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@@ Line 8: / Line 8: @@
 Laboratory findings consistent with the diagnosis of ''Chlamydial infection'' and its complications include:
-{| class="wikitable" style="border: 2; background: none;"
+{|style="border: 0px; font-size: 90%; margin: 3px;" align=center
-! colspan="1" rowspan="1" style="border: 1; background: 1;"| Type of Chlamydia
+!style="background: #4479BA; padding: 5px 5px;"| {{fontcolor|#FFFFFF|Type of Chlamydia}}
-! colspan="1" rowspan="1"| Tests
+!style="background: #4479BA; padding: 5px 5px;"| {{fontcolor|#FFFFFF|Tests}}
-! colspan="3" rowspan="1"| Findings
+!style="background: #4479BA; padding: 5px 5px;"| {{fontcolor|#FFFFFF|Findings}}
 |-
-! rowspan="2" style="border: 1; background: none;"| [[Neonatal Conjuctivitis]]
+!rowspan="2" style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;"| [[Neonatal Conjuctivitis]]
-| CBC || Normal
+|style="padding: 5px 5px; background: #F5F5F5;"| CBC
+|style="padding: 5px 5px; background: #F5F5F5;"| Normal
 |-
-| ESR || Normal
+|style="padding: 5px 5px; background: #F5F5F5;"| ESR
+|style="padding: 5px 5px; background: #F5F5F5;"| Normal
 |-
-! rowspan="3" style="border: 1; background: none;"| [[Neonatal pneumonia]]
+! rowspan="3" style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;"| [[Neonatal pneumonia]]
-| CBC || Absolute increase in eosinophil count
+|style="padding: 5px 5px; background: #F5F5F5;"| CBC
+|style="padding: 5px 5px; background: #F5F5F5;"| Absolute increase in eosinophil count
 |-
-| ESR || increased
+|style="padding: 5px 5px; background: #F5F5F5;" | ESR
+|style="padding: 5px 5px; background: #F5F5F5;" | Increased
 |-
-| CRP || increased
+|style="padding: 5px 5px; background: #F5F5F5;" | CRP
+|style="padding: 5px 5px; background: #F5F5F5;" | Increased
 |-
-! rowspan="3" style="border: 1; background: none;"| [[Genital infection]]
+! rowspan="4" style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;"| [[Genital infection]]
-| CBC || increased leukocyte count
+|style="padding: 5px 5px; background: #F5F5F5;"| CBC
+|style="padding: 5px 5px; background: #F5F5F5;"| Increased leukocyte count
 |-
-| Urinalysis || >5 WBCS per high power field
+|style="padding: 5px 5px; background: #F5F5F5;"| Urinalysis
+|style="padding: 5px 5px; background: #F5F5F5;"| >5 WBCS per high power field
 |-
-| ESR || normal or increased
+|style="padding: 5px 5px; background: #F5F5F5;"| ESR
+|style="padding: 5px 5px; background: #F5F5F5;"| Normal or increased
 |-
-| CRP || normal or increased
+|style="padding: 5px 5px; background: #F5F5F5;"| CRP
+|style="padding: 5px 5px; background: #F5F5F5;"| Normal or increased
 |-
-! rowspan="3" style="border: 1; background: none;"| [[Atypical pneumonia]]
+!style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;"| [[Atypical pneumonia]]
-| CBC || Increased absolute [[eosinophil]] count
+|style="padding: 5px 5px; background: #F5F5F5;"| CBC
+|style="padding: 5px 5px; background: #F5F5F5;"| Increased absolute [[eosinophil]] count
 |-
+! rowspan="4" style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;"| [[Fitz Hugh Curtis Syndrome]]
+|style="padding: 5px 5px; background: #F5F5F5;"| CBC
+|style="padding: 5px 5px; background: #F5F5F5;"| Increased leukocytes
+|-
+|style="padding: 5px 5px; background: #F5F5F5;"| LFTS
+|style="padding: 5px 5px; background: #F5F5F5;"| Normal
+|-
+|style="padding: 5px 5px; background: #F5F5F5;"| ESR
+|style="padding: 5px 5px; background: #F5F5F5;"| Normal or increased
+|-
+|style="padding: 5px 5px; background: #F5F5F5;"| D Dimer
+|style="padding: 5px 5px; background: #F5F5F5;"| Normal or increased
 |}
-Laboratory tests used in the diagnosis of chlamydia infection include nucleic acid amplification tests (NAAT) such as:
-*Polymerase chain reaction (PCR)
-*Transcription mediated amplification (TMA)
-*DNA strand displacement amplification (SDA)
-As of January 2007, the most commonly used and widely studied chlamydia NAATs in the US and many other industrialized countries are Aptima (Gen-Probe), Probe-Tec (Becton-Dickinson), and Amplicor (Roche).
-The Aptima Combo II assay tests simltaneously for C. trachomatis and [[Neisseria gonorrhoeae]], the cause of gonorrhea. [[NAAT]] for chlamydia may be performed on swab specimens collected from the [[cervix]] (women) or urethra (men), on self-collected vaginal swabs, or on voided urine. Urine and self-collected swab testing facilitates the performance of screening tests in settings where genital examination is impractical.
- At present, the NAATs have regulatory approval only for testing urogenital specimens, although rapidly evolving research indicates that the Aptima test may give reliable results on rectal specimens.
-Because of improved test accuracy, ease of specimen management, convenience in specimen management, and ease of screening sexually active men and women, the NAATs have largely replaced culture, the historic gold standard for chlamydia diagnosis, and the non-amplified probe tests, such as Pace II (Gen-Probe). The latter test is relatively insensitive, successfully detecting only 60-80% of infections in asymptomatic women, and often giving falsely positive results. Culture remains useful in selected circumstances and is currently the only assay approved for testing non-genital specimens.
 ==References==

Chlamydia infection laboratory findings: Difference between revisions

Revision as of 15:56, 9 September 2016

Overview

Laboratory Findings

References

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