Chlamydia infection laboratory findings: Difference between revisions
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::* Non amplified hybridization tests | ::* Non amplified hybridization tests | ||
'''Nucleic acid amplification tests(NAATS)''' | |||
*Higher sensitivity and specificity than culture | |||
*FDA approved for diagnosis | |||
*Recommended by CDC | |||
===Antibody detection tests=== | ===Antibody detection tests=== | ||
Revision as of 15:01, 12 September 2016
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Aysha Anwar, M.B.B.S[2]
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Overview
Laboratory findings consistent with the diagnosis of Chlamydial infection and its complications include:[1][2][3][4][5][6] [7]
Laboratory Findings
Laboratory findings consistent with the diagnosis of Chlamydial infection and its complications include:[1][2][3][8][5]
| Type of Chlamydia | Tests | Findings |
|---|---|---|
| Neonatal Conjuctivitis | CBC | Normal |
| ESR | Normal | |
| Neonatal pneumonia[1] | CBC | Absolute increase in eosinophil count |
| ESR | Increased | |
| CRP | Increased | |
| Genital infection[3][9][5] | CBC | Increased leukocyte count |
| Urinalysis | >5 WBCS per high power field | |
| ESR | Normal or increased | |
| CRP | Normal or increased | |
| Atypical pneumonia[10] | CBC | Increased or normal leukocyte count( lymphocytes) |
| Fitz Hugh Curtis Syndrome[2][3] | CBC | Increased leukocytes |
| LFTS | Normal | |
| ESR | Normal or increased | |
| D Dimer | Normal or increased |
Other diagnostic tests
The gold standard for the diagnosis of chlamydia infection is culture. However, other diagnostic tests used to diagnose chlamydia infection include
Culture
- Gold standard for diagnosing chlamydial infection
- Organism grows in cell culture
Direct Cytological test
- Used for diagnosing acute inclusion conjuctivitis in neonates
- Detects typical intracytoplasmic inclusions using giemsa stain
- Insensitive for diagnosing adult conjuctival and genital infection
Antigen detection tests
Antigen detection tests include the following
- Nucleic acid hybridization tests
- Non amplified hybridization tests
Nucleic acid amplification tests(NAATS)
- Higher sensitivity and specificity than culture
- FDA approved for diagnosis
- Recommended by CDC
Antibody detection tests
References
- ↑ 1.0 1.1 1.2 Lisowska P (1988). "The bridge to independence?". Br Dent J. 164 (5): 156–7. doi:10.1038/sj.bdj.4806386. PMID 3162806.
- ↑ 2.0 2.1 2.2 Stauffer ES (1973). "Closed injuries of the cervical spine and spinal cord flexion-rotation injuries". Proc Veterans Adm Spinal Cord Inj Conf (19): 47–8. PMID 4499951.
- ↑ 3.0 3.1 3.2 3.3 Yang HW, Jung SH, Han HY, Kim A, Lee YJ, Cha SW; et al. (2008). "[Clinical feature of Fitz-Hugh-Curtis syndrome: analysis of 25 cases]". Korean J Hepatol. 14 (2): 178–84. doi:10.3350/kjhep.2008.14.2.178. PMID 18617765.
- ↑ Peipert, Jeffrey F., et al. "Laboratory evaluation of acute upper genital tract infection." Obstetrics & Gynecology 87.5 (1996): 730-736.
- ↑ 5.0 5.1 5.2 Stamm WE, Cole B (1986). "Asymptomatic Chlamydia trachomatis urethritis in men". Sex Transm Dis. 13 (3): 163–5. PMID 3764626.
- ↑ Enwemeka CS, Rodriguez O, Mendosa S (1990). "The biomechanical effects of low-intensity ultrasound on healing tendons". Ultrasound Med Biol. 16 (8): 801–7. PMID 2095010.
- ↑ Centers for Disease Control and Prevention (2014). "Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae--2014". MMWR Recomm Rep. 63 (RR-02): 1–19. PMC 4047970. PMID 24622331.
- ↑ Peipert, Jeffrey F., et al. "Laboratory evaluation of acute upper genital tract infection." Obstetrics & Gynecology 87.5 (1996): 730-736.
- ↑ Peipert, Jeffrey F., et al. "Laboratory evaluation of acute upper genital tract infection." Obstetrics & Gynecology 87.5 (1996): 730-736.
- ↑ Hayashi Y, Asano T, Ito G, Yamada Y, Matsuura T, Adachi S; et al. (1993). "[Study of cell populations of bronchoalveolar lavage fluid in patients with pneumonia due to Chlamydia psittaci and Mycoplasma pneumoniae]". Nihon Kyobu Shikkan Gakkai Zasshi. 31 (5): 569–74. PMID 8331841.