Sandbox:Prince

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Prince	Tarek	Aysha
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Sandbox

Prince	Tarek	Aysha
Hello	Hi	Goodbye

The uterine cervix is the most common site of mucosal infection with N. gonorrhoeae in women (picture 1). Most women with cervical gonococcal infection, up to 70 percent in some series, are asymptomatic

   At least 86 (31%) of the 278 infections were in women who had pelvic inflammatory disease. These data indicate that the clinical spectrum of gonococcal infection varies according to where the patients are seen and that the widely held concept that most gonococcal infections in women are asymptomatic may be erroneous. 

AD

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SYMPTOMS:

Among 6230 women, prevalence of C trachomatis and N gonorrhoeae was 6.9% and 2.1%, respectively; 520 women (8.3%) had either organism detected. Age, cervical signs (mucopus, induced bleeding), and inflammation on endocervical GS were independently associated with infection. However, the positive predictive value (PPV) of any cervical finding for infection was less than 19% in women 25 years and older. Inflammation on endocervical GS was the sole indicator of infection in 79 of 520 (15%) infections, but was insensitive in the absence of mucopurulent cervicitis (sensitivity, 26%; PPV, 21%)

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When present, genital symptoms develop in most women within 10 days of exposure

Infection was more common among women with more than one exposure (13/14) than among those with one exposure (6/12). Gonococcal infection was significantly associated with the presence of findings on physical examination suggestive of upper genital tract inflammation.
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EPIDEMIOL

In about 30% of patients gonococci could be found in only one of the sites tested (cervix 18%, urethra 6%, rectum 4.8%, and throat 1.5%) 76760
In about 30% of patients gonococci could be found in only one of the sites tested (cervix 18%, urethra 6%, rectum 4.8%, and throat 1.5%)

COMPLICATION These infections are likely to be particularly important in promoting the sexual transmission and mother-to-child intrapartum transmission of HIV-1, and should therefore be the focus of HIV prevention strategies. 18685546

it may cause pregnancy and/or neonatal complications as a result of infection of the fetus, placenta, amniotic fluid, decidua, or membranes. In addition, cervicitis appears to be associated with a significant increase in risk of HIV-1 acquisition and shedding

There is no evidence that human papillomavirus infection (HPV) induces cervical inflammation, but it can cause other histologic changes (eg, cervical intraepithelial neoplasia). ?? SOURCE