Syphilis classification: Difference between revisions
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There is no established clasification system for syphilis. However, it may be classified into following subtypes:<ref name="pmid17235095">{{cite journal| author=French P| title=Syphilis. | journal=BMJ | year= 2007 | volume= 334 | issue= 7585 | pages= 143-7 | pmid=17235095 | doi=10.1136/bmj.39085.518148.BE | pmc=1779891 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17235095 }} </ref><ref name="pmid18208988[uid]">{{cite journal| author=Chakraborty R, Luck S| title=Syphilis is on the increase: the implications for child health. | journal=Arch Dis Child | year= 2008 | volume= 93 | issue= 2 | pages= 105-9 | pmid=18208988[uid] | doi=10.1136/adc.2006.103515 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18208988 }} </ref><ref name=abc>http://www.cdc.gov/std/stats10/app-casedef.htm Accessed on September 19, 2016</ref><ref name="pmid23324972">{{cite journal| author=Lago EG, Vaccari A, Fiori RM| title=Clinical features and follow-up of congenital syphilis. | journal=Sex Transm Dis | year= 2013 | volume= 40 | issue= 2 | pages= 85-94 | pmid=23324972 | doi=10.1097/OLQ.0b013e31827bd688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23324972 }} </ref><ref name="pmid16210105">{{cite journal| author=Woods CR| title=Syphilis in children: congenital and acquired. | journal=Semin Pediatr Infect Dis | year= 2005 | volume= 16 | issue= 4 | pages= 245-57 | pmid=16210105 | doi=10.1053/j.spid.2005.06.005 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16210105 }} </ref><ref name="pmid23324972">{{cite journal| author=Lago EG, Vaccari A, Fiori RM| title=Clinical features and follow-up of congenital syphilis. | journal=Sex Transm Dis | year= 2013 | volume= 40 | issue= 2 | pages= 85-94 | pmid=23324972 | doi=10.1097/OLQ.0b013e31827bd688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23324972 }} </ref><ref name="pmid6318372">{{cite journal| author=Rathbun KC| title=Congenital syphilis. | journal=Sex Transm Dis | year= 1983 | volume= 10 | issue= 2 | pages= 93-9 | pmid=6318372 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6318372 }} </ref><ref name="pmid15247352">{{cite journal| author=Hook EW, Peeling RW| title=Syphilis control--a continuing challenge. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 2 | pages= 122-4 | pmid=15247352 | doi=10.1056/NEJMp048126 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15247352 }} </ref><ref name="pmid16179782">{{cite journal| author=Kennedy JL, Barnard JJ, Prahlow JA| title=Syphilitic coronary artery ostial stenosis resulting in acute myocardial infarction and death. | journal=Cardiology | year= 2006 | volume= 105 | issue= 1 | pages= 25-9 | pmid=16179782 | doi=10.1159/000088337 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16179782 }} </ref><ref name="pmid9518283">{{cite journal| author=| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1998. A 46-year-old man with chest pain and coronary ostial stenosis. | journal=N Engl J Med | year= 1998 | volume= 338 | issue= 13 | pages= 897-903 | pmid=9518283 | doi=10.1056/NEJM199803263381308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9518283 }} </ref><ref name="pmid10194456">{{cite journal| author=Singh AE, Romanowski B| title=Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features. | journal=Clin Microbiol Rev | year= 1999 | volume= 12 | issue= 2 | pages= 187-209 | pmid=10194456 | doi= | pmc=88914 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10194456 }} </ref> | There is no established clasification system for syphilis. However, it may be classified into following subtypes:<ref name="pmid17235095">{{cite journal| author=French P| title=Syphilis. | journal=BMJ | year= 2007 | volume= 334 | issue= 7585 | pages= 143-7 | pmid=17235095 | doi=10.1136/bmj.39085.518148.BE | pmc=1779891 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17235095 }} </ref><ref name="pmid18208988[uid]">{{cite journal| author=Chakraborty R, Luck S| title=Syphilis is on the increase: the implications for child health. | journal=Arch Dis Child | year= 2008 | volume= 93 | issue= 2 | pages= 105-9 | pmid=18208988[uid] | doi=10.1136/adc.2006.103515 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18208988 }} </ref><ref name=abc>http://www.cdc.gov/std/stats10/app-casedef.htm Accessed on September 19, 2016</ref><ref name="pmid23324972">{{cite journal| author=Lago EG, Vaccari A, Fiori RM| title=Clinical features and follow-up of congenital syphilis. | journal=Sex Transm Dis | year= 2013 | volume= 40 | issue= 2 | pages= 85-94 | pmid=23324972 | doi=10.1097/OLQ.0b013e31827bd688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23324972 }} </ref><ref name="pmid16210105">{{cite journal| author=Woods CR| title=Syphilis in children: congenital and acquired. | journal=Semin Pediatr Infect Dis | year= 2005 | volume= 16 | issue= 4 | pages= 245-57 | pmid=16210105 | doi=10.1053/j.spid.2005.06.005 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16210105 }} </ref><ref name="pmid23324972">{{cite journal| author=Lago EG, Vaccari A, Fiori RM| title=Clinical features and follow-up of congenital syphilis. | journal=Sex Transm Dis | year= 2013 | volume= 40 | issue= 2 | pages= 85-94 | pmid=23324972 | doi=10.1097/OLQ.0b013e31827bd688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23324972 }} </ref><ref name="pmid6318372">{{cite journal| author=Rathbun KC| title=Congenital syphilis. | journal=Sex Transm Dis | year= 1983 | volume= 10 | issue= 2 | pages= 93-9 | pmid=6318372 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6318372 }} </ref><ref name="pmid15247352">{{cite journal| author=Hook EW, Peeling RW| title=Syphilis control--a continuing challenge. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 2 | pages= 122-4 | pmid=15247352 | doi=10.1056/NEJMp048126 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15247352 }} </ref><ref name="pmid16179782">{{cite journal| author=Kennedy JL, Barnard JJ, Prahlow JA| title=Syphilitic coronary artery ostial stenosis resulting in acute myocardial infarction and death. | journal=Cardiology | year= 2006 | volume= 105 | issue= 1 | pages= 25-9 | pmid=16179782 | doi=10.1159/000088337 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16179782 }} </ref><ref name="pmid9518283">{{cite journal| author=| title=Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1998. A 46-year-old man with chest pain and coronary ostial stenosis. | journal=N Engl J Med | year= 1998 | volume= 338 | issue= 13 | pages= 897-903 | pmid=9518283 | doi=10.1056/NEJM199803263381308 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9518283 }} </ref><ref name="pmid10194456">{{cite journal| author=Singh AE, Romanowski B| title=Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features. | journal=Clin Microbiol Rev | year= 1999 | volume= 12 | issue= 2 | pages= 187-209 | pmid=10194456 | doi= | pmc=88914 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10194456 }} </ref> | ||
=== Congenital=== | === Congenital=== | ||
: | :'''Early''' | ||
::* Manifests before 2 years of age | ::* Manifests before 2 years of age | ||
: | :'''Late''' | ||
::*Manifests after 2 years of age | ::*Manifests after 2 years of age | ||
Revision as of 21:39, 19 September 2016
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]
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Overview
Syphilis may be classified according to the development of disease into 2 groups: congenital and acquired. Acquired syphilis may be classified further into 5 subtypes: primary, secondary, latent and tertiary syphilis.
Classification
There is no established clasification system for syphilis. However, it may be classified into following subtypes:[1][2][3][4][5][4][6][7][8][9][10]
Congenital
- Early
- Manifests before 2 years of age
- Late
- Manifests after 2 years of age
Acquired
- Mode of transmission is direct contact with infectious lesion
- It may spread by sexual intercouse, touching and kissing a person having active lesions
Primary
Secondary
- Develops weeks to months after chancre[12]
- Manifests with constitutional sypmtoms such as fever, headache, malaise, lymphadenopathy and localised or diffuse rash called condyloma lata
- Lasts 1-6 months
Latent syphilis
- Early latent
- Asymptomatic < 12 years
- Late latent
- Asymptomatic >12 years
Tertiary or gummatous syphilis
References
- ↑ French P (2007). "Syphilis". BMJ. 334 (7585): 143–7. doi:10.1136/bmj.39085.518148.BE. PMC 1779891. PMID 17235095.
- ↑ Chakraborty R, Luck S (2008). "Syphilis is on the increase: the implications for child health". Arch Dis Child. 93 (2): 105–9. doi:10.1136/adc.2006.103515. PMID [uid 18208988[uid]] Check
|pmid=
value (help). - ↑ http://www.cdc.gov/std/stats10/app-casedef.htm Accessed on September 19, 2016
- ↑ 4.0 4.1 Lago EG, Vaccari A, Fiori RM (2013). "Clinical features and follow-up of congenital syphilis". Sex Transm Dis. 40 (2): 85–94. doi:10.1097/OLQ.0b013e31827bd688. PMID 23324972.
- ↑ Woods CR (2005). "Syphilis in children: congenital and acquired". Semin Pediatr Infect Dis. 16 (4): 245–57. doi:10.1053/j.spid.2005.06.005. PMID 16210105.
- ↑ Rathbun KC (1983). "Congenital syphilis". Sex Transm Dis. 10 (2): 93–9. PMID 6318372.
- ↑ Hook EW, Peeling RW (2004). "Syphilis control--a continuing challenge". N Engl J Med. 351 (2): 122–4. doi:10.1056/NEJMp048126. PMID 15247352.
- ↑ 8.0 8.1 Kennedy JL, Barnard JJ, Prahlow JA (2006). "Syphilitic coronary artery ostial stenosis resulting in acute myocardial infarction and death". Cardiology. 105 (1): 25–9. doi:10.1159/000088337. PMID 16179782.
- ↑ "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1998. A 46-year-old man with chest pain and coronary ostial stenosis". N Engl J Med. 338 (13): 897–903. 1998. doi:10.1056/NEJM199803263381308. PMID 9518283.
- ↑ Singh AE, Romanowski B (1999). "Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features". Clin Microbiol Rev. 12 (2): 187–209. PMC 88914. PMID 10194456.
- ↑ Musher, Daniel M. "Early syphilis." Sexually Transmitted Diseases. 3rd ed. New York: McGraw-Hill (1999): 479-487.
- ↑ Chapel TA (1980). "The signs and symptoms of secondary syphilis". Sex Transm Dis. 7 (4): 161–4. PMID 7455863.
- ↑ Pereira TM, Fernandes JC, Vieira AP, Basto AS (2007). "Tertiary syphilis". Int J Dermatol. 46 (11): 1192–5. doi:10.1111/j.1365-4632.2007.03438.x. PMID 17988342.
- ↑ Berger JR, Dean D (2014). "Neurosyphilis". Handb Clin Neurol. 121: 1461–72. doi:10.1016/B978-0-7020-4088-7.00098-5. PMID 24365430.