Sandbox:AA

Aysha's sandbox

Stage of syphilis	History and symptoms
Primary syphilis	Onset within 3 weeks of contact Chancre: Rapidly progresses an ulcerated, indurated lesion Single painless firm raised papule Usually located on the glans penis, cervix, labia, anal canal, rectum or oral cavity Regional lymphadenopathy Heals spontaneously within 4-6 weeks; however, regional lymphadenopathy may persist for longer periods.
Secondary syphilis	Develops 6-8 weeks after the appearance of primary chancre Generalized systemic symptoms such as malaise, fatigue, headache and fever may be present. Skin eruptions may be subtle and asymptomatic Classic: Non-pruritic bilateral symmetrical mucocutaneous rash Non-tender regional lymphadenopathy Condylomata lata Patchy alopecia
Latent syphilis	Previous history of chancre or rash Asymptomatic
Tertiary syphilis	Clinical manifestation of this stage depends on organ system involved: Neurosyphilis Altered mental status Dementia Focal neurodeficit affecting hearing and vision Cardiovascular syphilis Gummatous lesions

MRI syphilis 17628376