Erythrasma pathophysiology: Difference between revisions
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**Penetration of the skin occurs when the horny [[cells]] of the [[plasma]] [[membranes]] rupture . | **Penetration of the skin occurs when the horny [[cells]] of the [[plasma]] [[membranes]] rupture . | ||
**Keratolysis occurs due to the removal of [[keratin]] [[fibrils]] from the [[bacteria]], leading to the formation of reddish-brown [[lesions]] characteristic of Erythrasma. | **Keratolysis occurs due to the removal of [[keratin]] [[fibrils]] from the [[bacteria]], leading to the formation of reddish-brown [[lesions]] characteristic of Erythrasma. | ||
***The exact cause, chemical or systemic, of the keratolysis is unknown.<ref name="Raubitschek1962">{{cite journal|last1=Raubitschek|first1=F.|title=Mechanical versus chemical keratolysis by dermatophytes|journal=Medical Mycology|volume=1|issue=2|year=1962|pages=87–90|issn=1369-3786|doi=10.1080/00362176285190191}}</ref> | |||
==Microscopic Pathology== | |||
*Erythrasma presents with the following microscopic findings:<ref name="MontesBlack1967">{{cite journal|last1=Montes|first1=Leopoldo F.|last2=Black|first2=S.H.|last3=McBride|first3=Mollie E.|title=Bacterial Invasion of the Stratum Corneum in Erythrasma|journal=Journal of Investigative Dermatology|volume=49|issue=5|year=1967|pages=474–485|issn=0022202X|doi=10.1038/jid.1967.168}}</ref> | |||
**Thickening of [[stratum corneum]] without signs of parakeratosis | |||
**Largest concentration of ''[[Corynebacterium|Corynebacterium minitissium]]'' in the upper third of the [[stratum corneum]] | |||
**Widening of intracelluar space, allowing [[bacterial]] invasion, and separation of the horny [[cells]] | |||
**Disappearance of [[plasma]] [[cell]] [[membranes]] at the sites of ''[[Corynebacterium|Corynebacterium minitissium]]'' infiltration. | |||
**Decreased [[electron]] density around intracellular [[bacteria]] and those in direct contact with the [[cell]] wall | |||
** | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 18:41, 28 September 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Pathophysiology
Pathogenesis
- Erythrasma develops when Corynebacterium minitissium infiltrates the stratum corneum and proliferate.[1]
- The bacteria proliferates on the epidermis and develops at the intracellular level of the stratum corneum.
- Penetration of the skin occurs when the horny cells of the plasma membranes rupture .
- Keratolysis occurs due to the removal of keratin fibrils from the bacteria, leading to the formation of reddish-brown lesions characteristic of Erythrasma.
- The exact cause, chemical or systemic, of the keratolysis is unknown.[2]
Microscopic Pathology
- Erythrasma presents with the following microscopic findings:[1]
- Thickening of stratum corneum without signs of parakeratosis
- Largest concentration of Corynebacterium minitissium in the upper third of the stratum corneum
- Widening of intracelluar space, allowing bacterial invasion, and separation of the horny cells
- Disappearance of plasma cell membranes at the sites of Corynebacterium minitissium infiltration.
- Decreased electron density around intracellular bacteria and those in direct contact with the cell wall
References
- ↑ 1.0 1.1 Montes, Leopoldo F.; Black, S.H.; McBride, Mollie E. (1967). "Bacterial Invasion of the Stratum Corneum in Erythrasma". Journal of Investigative Dermatology. 49 (5): 474–485. doi:10.1038/jid.1967.168. ISSN 0022-202X.
- ↑ Raubitschek, F. (1962). "Mechanical versus chemical keratolysis by dermatophytes". Medical Mycology. 1 (2): 87–90. doi:10.1080/00362176285190191. ISSN 1369-3786.