Erythrasma pathophysiology: Difference between revisions
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*[[Tinea pedis]] | *[[Tinea pedis]] | ||
*[[Tinea versicolor]]<ref name="pmid19988837">{{cite journal |vauthors=Whittle CH |title=Tinea Versicolor of the Trunk and Groins Simulating Erythrasma |journal=Proc. R. Soc. Med. |volume=25 |issue=8 |pages=1318–9 |year=1932 |pmid=19988837 |pmc=2184180 |doi= |url=}}</ref> | *[[Tinea versicolor]]<ref name="pmid19988837">{{cite journal |vauthors=Whittle CH |title=Tinea Versicolor of the Trunk and Groins Simulating Erythrasma |journal=Proc. R. Soc. Med. |volume=25 |issue=8 |pages=1318–9 |year=1932 |pmid=19988837 |pmc=2184180 |doi= |url=}}</ref> | ||
*[[Intertrigo]]<ref name="pmid24695603">{{cite journal |vauthors=Kalra MG, Higgins KE, Kinney BS |title=Intertrigo and secondary skin infections |journal=Am Fam Physician |volume=89 |issue=7 |pages=569–73 |year=2014 |pmid=24695603 |doi= |url=}}</ref> | |||
*[[Psoriasis]]<ref name="pmid12010076">{{cite journal |vauthors=Holdiness MR |title=Management of cutaneous erythrasma |journal=Drugs |volume=62 |issue=8 |pages=1131–41 |year=2002 |pmid=12010076 |doi= |url=}}</ref> | |||
*[[Dermatophytosis]] | |||
*[[Candidiasis]] | |||
==References== | ==References== | ||
Revision as of 20:09, 28 September 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Pathophysiology
Pathogenesis
- Erythrasma develops when Corynebacterium minitissium infiltrates the stratum corneum and proliferate.[1]
- The bacteria proliferates on the epidermis and develops at the intracellular level of the stratum corneum.
- Penetration of the skin occurs when the horny cells of the plasma membranes rupture .
- Keratolysis occurs due to the removal of keratin fibrils from the bacteria.
- The exact cause, chemical or systemic, of the keratolysis is unknown.[2]
- Hyperkeratosis leads to the formation of reddish-brown lesions characteristic of Erythrasma.[3]
Microscopic Pathology
- Erythrasma presents with the following microscopic findings:[1]
- Thickening of stratum corneum without signs of parakeratosis
- Largest concentration of Corynebacterium minitissium in the upper third of the stratum corneum
- Widening of intracelluar space, allowing bacterial invasion, and separation of the horny cells
- Disappearance of plasma cell membranes at the sites of Corynebacterium minitissium infiltration.
- Decreased electron density around intracellular bacteria and those in direct contact with the cell wall
Associated Conditions
Erythrasma is associated with the following dermatological conditions:
- Other cornyebacterium-infection pathologies:[4]
- Pitted keratolysis
- Trichobacteriosis
- Tinea pedis
- Tinea versicolor[5]
- Intertrigo[6]
- Psoriasis[7]
- Dermatophytosis
- Candidiasis
References
- ↑ 1.0 1.1 Montes, Leopoldo F.; Black, S.H.; McBride, Mollie E. (1967). "Bacterial Invasion of the Stratum Corneum in Erythrasma". Journal of Investigative Dermatology. 49 (5): 474–485. doi:10.1038/jid.1967.168. ISSN 0022-202X.
- ↑ Raubitschek, F. (1962). "Mechanical versus chemical keratolysis by dermatophytes". Medical Mycology. 1 (2): 87–90. doi:10.1080/00362176285190191. ISSN 1369-3786.
- ↑ Montes LF, McBride ME, Johnson WP, Owens DW, Knox JM (1965). "Ultrastructural study of the host-bacterium relationship in erythrasma". J. Bacteriol. 90 (5): 1489–91. PMC 315839. PMID 5848336.
- ↑ Pinto M, Hundi GK, Bhat RM, Bala NK, Dandekeri S, Martis J, Kambil SM (2016). "Clinical and epidemiological features of coryneform skin infections at a tertiary hospital". Indian Dermatol Online J. 7 (3): 168–73. doi:10.4103/2229-5178.182351. PMC 4886587. PMID 27294050.
- ↑ Whittle CH (1932). "Tinea Versicolor of the Trunk and Groins Simulating Erythrasma". Proc. R. Soc. Med. 25 (8): 1318–9. PMC 2184180. PMID 19988837.
- ↑ Kalra MG, Higgins KE, Kinney BS (2014). "Intertrigo and secondary skin infections". Am Fam Physician. 89 (7): 569–73. PMID 24695603.
- ↑ Holdiness MR (2002). "Management of cutaneous erythrasma". Drugs. 62 (8): 1131–41. PMID 12010076.