Heparin-induced thrombocytopenia diagnostic criteria: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Heparin-induced thrombocytopenia}} | {{Heparin-induced thrombocytopenia}} | ||
{{CMG}}; | {{CMG}}; {{shyam}} | ||
==Overview== | ==Overview== | ||
The | ===The 4T score=== | ||
The current diagnostic algorithm for HIT involves calculation of the pre-test probability using the 4T score. This scoring system is used when a patient is found to have thrombocytopenia or thrombosis after heparin exposure. It is calculated before the heparin-PF4 IgG antibody is ordered, and it offers a cost-effective and efficient way for determining the likelihood of HIT.<ref name="pmid24824208">{{cite journal| author=Gardiner EE, Andrews RK, Cuker A| title=DiagnoSTic assays for heparin-induced thrombocytopenia. | journal=Br J Haematol | year= 2014 | volume= 166 | issue= 5 | pages= 631-3 | pmid=24824208 | doi=10.1111/bjh.12940 | pmc=4134688 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24824208 }} </ref> | |||
* '''T'''hrmobocytopenia | |||
* '''T'''hrombosis | |||
* '''T'''iming | |||
* o'''T'''her | |||
<ref name="pmid22990018">{{cite journal| author=Cuker A, Gimotty PA, Crowther MA, Warkentin TE| title=Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis. | journal=Blood | year= 2012 | volume= 120 | issue= 20 | pages= 4160-7 | pmid=22990018 | doi=10.1182/blood-2012-07-443051 | pmc=3501714 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22990018 }} </ref> | |||
* 0 to 3 points: low probability | * 0 to 3 points: low probability | ||
Revision as of 22:44, 9 July 2017
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Heparin-induced thrombocytopenia |
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Differentiating Heparin-induced thrombocytopenia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Shyam Patel [2]
Overview
The 4T score
The current diagnostic algorithm for HIT involves calculation of the pre-test probability using the 4T score. This scoring system is used when a patient is found to have thrombocytopenia or thrombosis after heparin exposure. It is calculated before the heparin-PF4 IgG antibody is ordered, and it offers a cost-effective and efficient way for determining the likelihood of HIT.[1]
- Thrmobocytopenia
- Thrombosis
- Timing
- oTher
- 0 to 3 points: low probability
- 4 to 5 points: intermediate probability
- 6 to 8 points: high probability
The American Society of Hematology, as part of the Choosing Wisely program, states[3]:
- "Don’t test or treat for suspected heparin-induced thrombocytopenia (HIT) in patients with a low pre-test probability of HIT."
Diagnostic Criteria
Reference
- ↑ Gardiner EE, Andrews RK, Cuker A (2014). "DiagnoSTic assays for heparin-induced thrombocytopenia". Br J Haematol. 166 (5): 631–3. doi:10.1111/bjh.12940. PMC 4134688. PMID 24824208.
- ↑ Cuker A, Gimotty PA, Crowther MA, Warkentin TE (2012). "Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis". Blood. 120 (20): 4160–7. doi:10.1182/blood-2012-07-443051. PMC 3501714. PMID 22990018.
- ↑ The American Society of Hematology. test or treat for suspected heparin-induced thrombocytopenia (HIT) in patients with a low pre-test probability of HIT.. 2014