IgA nephropathy overview: Difference between revisions
Olufunmilola (talk | contribs) No edit summary |
Olufunmilola (talk | contribs) |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
IgA nephropathy (Berger’s disease) is considered the most common primary chronic glomerulonephritis.<ref name="pmid3329736">{{cite journal| author=D'Amico G| title=The commonest glomerulonephritis in the world: IgA nephropathy. | journal=Q J Med | year= 1987 | volume= 64 | issue= 245 | pages= 709-27 | pmid=3329736 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3329736 }} </ref> The clinical syndrome of IgA nephropathy is often unpredictable, although classically it is recognized as a nephritic syndrome with a presentation of recurrent painless gross hematuria following a respiratory or gastrointestinal tract infection in a young male patient. Nonetheless, asymptomatic IgA nephropathy with microscopic hematuria is not uncommon.<ref name="pmid12213946">{{cite journal| author=Donadio JV, Grande JP| title=IgA nephropathy. | journal=N Engl J Med | year= 2002 | volume= 347 | issue= 10 | pages= 738-48 | pmid=12213946 | doi=10.1056/NEJMra020109 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12213946 }} </ref> Although not frequently performed, the definitive diagnosis to confirm the clinical suspicion of IgA nephropathy is kidney biopsy that not only carries diagnostic benefit, but also has prognostic implications. | IgA nephropathy (Berger’s disease) is considered the most common primary chronic glomerulonephritis.<ref name="pmid3329736">{{cite journal| author=D'Amico G| title=The commonest glomerulonephritis in the world: IgA nephropathy. | journal=Q J Med | year= 1987 | volume= 64 | issue= 245 | pages= 709-27 | pmid=3329736 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3329736 }} </ref> IgA nephropathy is defined immune-histologically by mesangial deposits of IgA, often accompanied by less intense staining for IgM and/or IgG and C3, in the absence of a systemic disease <ref name="pmid3337116">{{cite journal| author=Julian BA, Waldo FB, Rifai A, Mestecky J| title=IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States? | journal=Am J Med | year= 1988 | volume= 84 | issue= 1 | pages= 129-32 | pmid=3337116 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3337116 }} </ref>. IgAN has been differentiated from Henoch- Schönlein purpura (HSP), which is clearly a systemic illness with vasculitis. | ||
The clinical syndrome of IgA nephropathy is often unpredictable, although classically it is recognized as a nephritic syndrome with a presentation of recurrent painless gross hematuria following a respiratory or gastrointestinal tract infection in a young male patient. Nonetheless, asymptomatic IgA nephropathy with microscopic hematuria is not uncommon.<ref name="pmid12213946">{{cite journal| author=Donadio JV, Grande JP| title=IgA nephropathy. | journal=N Engl J Med | year= 2002 | volume= 347 | issue= 10 | pages= 738-48 | pmid=12213946 | doi=10.1056/NEJMra020109 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12213946 }} </ref> Although not frequently performed, the definitive diagnosis to confirm the clinical suspicion of IgA nephropathy is kidney biopsy that not only carries diagnostic benefit, but also has prognostic implications. | |||
==References== | ==References== | ||
Revision as of 16:09, 1 November 2016
|
IgA nephropathy Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
IgA nephropathy overview On the Web |
|
American Roentgen Ray Society Images of IgA nephropathy overview |
|
Risk calculators and risk factors for IgA nephropathy overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
IgA nephropathy (Berger’s disease) is considered the most common primary chronic glomerulonephritis.[1] IgA nephropathy is defined immune-histologically by mesangial deposits of IgA, often accompanied by less intense staining for IgM and/or IgG and C3, in the absence of a systemic disease [2]. IgAN has been differentiated from Henoch- Schönlein purpura (HSP), which is clearly a systemic illness with vasculitis.
The clinical syndrome of IgA nephropathy is often unpredictable, although classically it is recognized as a nephritic syndrome with a presentation of recurrent painless gross hematuria following a respiratory or gastrointestinal tract infection in a young male patient. Nonetheless, asymptomatic IgA nephropathy with microscopic hematuria is not uncommon.[3] Although not frequently performed, the definitive diagnosis to confirm the clinical suspicion of IgA nephropathy is kidney biopsy that not only carries diagnostic benefit, but also has prognostic implications.
References
- ↑ D'Amico G (1987). "The commonest glomerulonephritis in the world: IgA nephropathy". Q J Med. 64 (245): 709–27. PMID 3329736.
- ↑ Julian BA, Waldo FB, Rifai A, Mestecky J (1988). "IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States?". Am J Med. 84 (1): 129–32. PMID 3337116.
- ↑ Donadio JV, Grande JP (2002). "IgA nephropathy". N Engl J Med. 347 (10): 738–48. doi:10.1056/NEJMra020109. PMID 12213946.