IgA nephropathy causes: Difference between revisions
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==Causes== | ==Causes== | ||
===Primary IgA Nephropathy=== | ===Primary IgA Nephropathy=== | ||
The cause of primary IgA nephropathy is unknown. There are also no infectious or environmental associated factors. But, some studies had associated some genetic mutations and familial clustering as postulated cause of IgAN <ref name="pmid10792601">{{cite journal| author=Hsu SI, Ramirez SB, Winn MP, Bonventre JV, Owen WF| title=Evidence for genetic factors in the development and progression of IgA nephropathy. | journal=Kidney Int | year= 2000 | volume= 57 | issue= 5 | pages= 1818-35 | pmid=10792601 | doi=10.1046/j.1523-1755.2000.00032.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10792601 }} </ref>. These studies are inconclusive and there are more ongoing researches in this area. | |||
Primary IgA nephropathy is caused by a genetic predisposition in patients who typically present immediately following a respiratory or gastrointestinal tract infectious organisms or virus. The environmental exposure to these infectious agents may thus facilitate the subsequent pathogenesis of the disease. | Primary IgA nephropathy is caused by a genetic predisposition in patients who typically present immediately following a respiratory or gastrointestinal tract infectious organisms or virus. The environmental exposure to these infectious agents may thus facilitate the subsequent pathogenesis of the disease. | ||
Revision as of 16:45, 1 November 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
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Overview
Causes
Primary IgA Nephropathy
The cause of primary IgA nephropathy is unknown. There are also no infectious or environmental associated factors. But, some studies had associated some genetic mutations and familial clustering as postulated cause of IgAN [1]. These studies are inconclusive and there are more ongoing researches in this area. Primary IgA nephropathy is caused by a genetic predisposition in patients who typically present immediately following a respiratory or gastrointestinal tract infectious organisms or virus. The environmental exposure to these infectious agents may thus facilitate the subsequent pathogenesis of the disease.
Secondary IgA Nephropathy
Common primary etiologies associated with glomerular IgA deposits and thus secondary IgA nephropathy are shown below.
The most important 3 causes are:
- Liver cirrhosis[2]
- Celiac disease[2]
- HIV infection[2]
IgA nephropathy has also been associated with the following diseases, but to a much less extent:
- Dermatitis herpetiformis[2]
- Seronegative arthritis, especially as ankylosing spondylitis[2]
- Small-cell carcinoma[2]
- Hodgkin’s lymphoma[2]
- T-cell lymphoma, such as mycosis fungoides[2]
- Disseminated tuberculosis[2]
- Bronchiolitis obliterans[2]
- Inflammatory bowel disease (Crohn’s disease and ulcerative colitis)[2]
References
- ↑ Hsu SI, Ramirez SB, Winn MP, Bonventre JV, Owen WF (2000). "Evidence for genetic factors in the development and progression of IgA nephropathy". Kidney Int. 57 (5): 1818–35. doi:10.1046/j.1523-1755.2000.00032.x. PMID 10792601.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Radhakrishnan J, Cattran DC (2012). "The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines--application to the individual patient". Kidney Int. 82 (8): 840–56. doi:10.1038/ki.2012.280. PMID 22895519.