Pancreatic insufficiency: Difference between revisions
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{{CMG}}; {{AE}} {{VSKP}} | {{CMG}}; {{AE}} {{VSKP}} | ||
{{SK}} Exocrine pancreatic insufficiency | |||
== Overview == | == Overview == | ||
Revision as of 20:17, 2 November 2016
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [2]
Synonyms and keywords: Exocrine pancreatic insufficiency
Overview
Pancreatic insufficiency is characterized by deficiency of the exocrine pancreatic enzymes, resulting in the inability to digest food properly, or maldigestion.
Causes
Common causes of Pancreatic insufficiency
- Chronic alcoholism
- Chronic pancreatitis
- Cystic fibrosis
- Gall stones
- Gastrectomy
- Shwachman-Diamond syndrome
- Zollinger-Ellison syndrome
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | Diabetic gastroparesis, Hyperparathyroidism |
| Environmental | No underlying causes |
| Gastroenterologic | Chronic pancreatitis, Cystic fibrosis, Diabetic gastroparesis, Gallstones, Hemochromatosis |
| Genetic | Alpha 1-antitrypsin deficiency, Annular pancreas, Ataxia telangiectasia, Congenital lipomatosis of pancreas, Congenital pancreatic dysfunction, Congenital partial lipodystrophy, Cystic fibrosis, Havlikova syndrome, Hemochromatosis, Hereditary pancreatitis, Homocystinuria, Johanson-blizzard syndrome, Juvenile tropical pancreatitis syndrome, Pancreatic agenesis, Pearson syndrome, Shwachman-Diamond syndrome, Situs inversus totalis with cystic dysplasia of pancreas, Wolfram's disease |
| Hematologic | Acute intermittent porphyria |
| Iatrogenic | Pancreatectomy, Partial or total gastrectomy |
| Infectious Disease | Mumps |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | Gestational diabetes |
| Oncologic | Pancreatic cancer, Zollinger-Ellison syndrome |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | Autoimmune lymphoproliferative syndrome, Lupus, Polyglandular autoimmune syndrome, Sjogren's syndrome, |
| Sexual | No underlying causes |
| Trauma | Trauma |
| Urologic | No underlying causes |
| Miscellaneous | Chronic alcoholism, Pancreatic cyst, Pancreatic duct obstruction, Pancreatic pseudocyst |
Causes in Alphabetical Order
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3Diagnosis
History and Symptoms
Differential Diagnosis of Causes of Pancreatic insufficiency
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3Treatment
Often this is treated with Pancreatic Enzyme Products (PEPs), such as pancrelipase, that are used to breakdown fats (lipases), proteins (proteases) and carbohydrates (amylases) into units that can be digested by those with EPI. [1]
References