Primary hypertriglyceridemia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Usama Talib, BSc, MD [2]

Overview

Primary hypertriglyceridemia i.e type 4 hyper lipidemia is due to high concentration of triglycerides in the blood. It is also known as hypertriglyceridemia (or pure hypertriglyceridemia). According to the NCEP-ATPIII definition of high triglycerides (>200 mg/dl), prevalence is about 16% of adult population. Elevated levels of triglycerides can be detrimental for the normal cardiac functioning.

Natural History, Complications, and Prognosis

A large number of people in the US have a high level of triglycerides (>150mg/dl) that can lead to numerous complications including

• Cardiovascular diseases
• Non Alcoholic Fatty Liver Disease (NAFLD)
• Pancreatitis

Medical Therapy

The medical therapy of hypertriglyceridemia varies according to the level of triglycerides found in the body. Moderate increase i.e >500 can be treated by statins while severe increase that is >1000 need to be treated by using a fibrate as the primary treatment.